Discrepancies of SARS-CoV-2 testing results among patients with total laryngectomy

Fabbris, Cristoforo; Boaria, F; Boscolo‐Rizzo, Paolo; Emanuelli, Enzo; Spinato, Giacomo

doi:10.1007/s00405-021-07203-8

Cited by 4 publications

(2 citation statements)

References 19 publications

(20 reference statements)

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“…The discordance of upper and lower respiratory samples has been previously documented. Specifically, a recent study evaluated differences between swab results in the trachea and in the nasopharynx in 25 totally laryngectomized subjects, showing that results were overall divergent and no statistically significant correlations emerged between results of the tests performed in the two sites, suggesting that both tracheal and nasopharyngeal swabs are recommended in these kinds of patients, to obtain a reliable test and to avoid false negatives ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Very High Negative Concordance Rate of RT-PCR for SARS-CoV-2 in Nasopharyngeal Swab and Tracheo-Bronchial Aspirate in Children

et al. 2022

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Reliable testing methods for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children are essential to allow normal activities. Diagnosis of SARS-CoV-2 infection is currently based on real-time reverse transcriptase-polymerase chain reaction (RT-PCR) performed on nasopharyngeal (NP) swabs; concerns have been raised regarding NP swab accuracy in children to detect the virus because of potential lack of cooperation of the patients or due to general uncertainties about concordance between high and low respiratory tract specimens in children. The aim of the study (IRB approval: ST/2020/405) is to prospectively compare RT-PCR results on NP and tracheo-bronchial aspirate (TA) in children admitted to the hospital for surgery or admitted to the Pediatric Intensive Care Unit (PICU) of a tertiary children hospital in Milano, Italy, during a peak of COVID-19 infections in the city. A total of 385 patients were enrolled in the study: 364 from surgical theater and 21 from PICU. Two patients (0.5%) tested positive on TA and were negative on NP; both cases occurred in November 2020, during a peak of infection in the city. Specificity of NP swab was.995 (95% CI: 0.980–0.999). Two patients with positive NP swabs tested negative on TA.ConclusionOur study shows that the specificity of SARS-CoV-2 RT-PCR on TA swab, compared to results of SARS-CoV-2 RT-PCR on NP, was very high for negative cases in our pediatric cohort during a period of high epidemiological pressure.

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Section: Discussionmentioning

confidence: 99%

Very High Negative Concordance Rate of RT-PCR for SARS-CoV-2 in Nasopharyngeal Swab and Tracheo-Bronchial Aspirate in Children

et al. 2022

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“…[22,23] The relationship between COVID-19 and total laryngectomy patients was mentioned in two studies. [24][25][26] One of these studies reported that COVID-19 may show a more severe clinical course. [24] In our study, we found that COVID-19 was less frequent in total laryngectomy patients compared to the control (p=0.001).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 in patients with total laryngectomy

Yılmaz¹

2022

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Bu çalışmada total larenjektomili hastalarda koronavirüs hastalığı 2019 (COVID-19) hastalığının sıklığı ve klinik şiddeti incelendi. Hastalar ve Yöntemler: Bu retrospektif çalışma 114 katılımcı (102 erkek, 12 kadın; ort. yaş: 65.9±10.4 yıl; dağılım, 40-90 yıl) ile yürütüldü. Çalışma grubuna Haziran 2014 -Haziran 2018 tarihleri arasında kliniğimizde total larenjektomi ameliyatı geçiren 57 hasta dahil edildi. Kliniğimize başvuran sağlıklı bireyler arasından 57 kişi kontrol grubuna dahil edildi. Çalışma gruplarında COVID-19'un sıklığı tespit edildi. Hastaların COVID-19 semptomlarının şiddeti sorgulandı ve elde edilen veriler analiz edildi. Bulgular: Çalışma grubu 52 (%91.2) erkek ve beş (%8.8) kadın hastadan, kontrol grubu ise 50 (%87.7) erkek ve yedi (%12.3) kadın katılımcıdan oluştu. Grupların yaş ortalamaları çalışma grubu için 65.9±10.4 yıl (medyan yaş: 65 yıl; dağılım, 40-92 yıl), kontrol grubu için 65.7±11.0 yıl (medyan yaş: 65 yıl; dağılım, 40-94 yıl) idi. Çalışma grubundaki COVID-19 görülme oranı, kontrol grubuna kıyasla anlamlı derecede düşüktü (p=0.001). COVID-19 semptomlarının değerlendirilmesinde, öksürük ve koku bozukluğu semptomları Çalışma grubunda anlamlı olarak daha şiddetli bulundu (sırasıyla, p=0.001, p=0.001). Çalışma grubunda yatan hasta sayısı kontrol grubuna kıyasla anlamlı derecede fazlaydı (p=0.015). Sonuç: COVID-19 sıklığı total larenjektomili hastalarda normal popülasyona kıyasla düşük olabilir. Bununla birlikte COVID-19 kliniği total larenjektomili hastalarda normal popülasyona göre daha ağır seyrediyor olabilir.

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Usage of Heat and Moisture Exchange Devices, Virtual Visits, Masking, and Vaccinations Among People With a Laryngectomy During COVID-19

Searl

Genoa

Fritz

et al. 2023

Am J Speech Lang Pathol

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Purpose: This study described the COVID-19 risk mitigation actions of people with a total laryngectomy (TL) during the pandemic. Method: An online survey was completed by 215 people with a TL who lived in the United States. The survey was open from December 1, 2021, to January 15, 2022. Results: There was a significant increase in frequency of heat and moisture exchange (HME) device use during the pandemic compared with pre–COVID-19. Frequency of HME use was significantly greater for those who were vaccinated and those who had at least one clinical visit with their speech-language pathologist (SLP). The use of virtual visits increased from 9% pre–COVID-19 to 37% during the pandemic. Seventy percent of respondents were “satisfied” or “very satisfied” with virtual visits and 51% judged them “as good as in-person.” Eighty percent were vaccinated for COVID-19 and 75% received a booster. One third reported that they did not wear mask over the face or over the tracheostoma. Twenty percent had tested positive for COVID-19 with 70% of these people requiring hospitalization. Conclusions: HME use and virtual SLP visits increased during the pandemic and the vaccination rate was high among this group of respondents. Overall, there were still large percentages of people with a TL who were not using an HME, not vaccinated, and did not wear a mask. SLPs should consider reaching out directly to their TL caseload, particularly those not yet seen during the pandemic, to support uptake of COVID-19 mitigation activities specific to people with a TL as the pandemic persists.

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Discrepancies of SARS-CoV-2 testing results among patients with total laryngectomy

Cited by 4 publications

References 19 publications

Very High Negative Concordance Rate of RT-PCR for SARS-CoV-2 in Nasopharyngeal Swab and Tracheo-Bronchial Aspirate in Children

Very High Negative Concordance Rate of RT-PCR for SARS-CoV-2 in Nasopharyngeal Swab and Tracheo-Bronchial Aspirate in Children

COVID-19 in patients with total laryngectomy

Usage of Heat and Moisture Exchange Devices, Virtual Visits, Masking, and Vaccinations Among People With a Laryngectomy During COVID-19

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