Discrepancies in Brain Tumor Extent as Shown by Computed Tomography and Positron Emission Tomography Using [68Ga]EDTA, [11C]Glucose, and [11C]Methionine

Delineation of Brain Tumor Extent with [11C]l-Methionine Positron Emission Tomography

“…Twenty-nine of 53 specimens in malignant astrocytoma grade 3 and 4 presented with no signs of contrast enhancement but showed increased [ 11 C]MET uptake similar to findings of Bergstrom et al (29) who demonstrated that Ͼ50% of the tumor would have not been detected on contrast enhanced CT alone. MRI and CT are necessary for stereotactic biopsy planing because morphologic information of location of blood vessels and eloquent brain areas is needed, and therefore, [ 11 C]MET-PET is an additional investigation that can give important information about target for biopsy and tumor extent to the neurosurgeon but cannot be evaluated without MRI.…”

“…Endothelial proliferation and necrosis are associated with breakdown of the blood-brain barrier and often show contrast enhancement in MRI or CT (3,29). Twenty-nine of 53 specimens in malignant astrocytoma grade 3 and 4 presented with no signs of contrast enhancement but showed increased [ 11 C]MET uptake similar to findings of Bergstrom et al (29) who demonstrated that Ͼ50% of the tumor would have not been detected on contrast enhanced CT alone.…”

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

“…Few studies have compared FDG and MET; they have demonstrated that FDG is probably better for establishing the degree of malignancy, whereas MET better delineates the lesions, especially low-grade gliomas [319,321,323,353,354].…”

Preoperative Estimation and Resection of Gliomas Using Positron Emission Tomography/Computed Tomography Neuronavigation

“…In addition, fusion of MET with MRI or CT images allowed for better detection of lowgrade tumors close to the cortex, smaller tumors, and tumor boundaries. Therefore, combined use of FDG and MET is reasonable in detecting regional malignancy and in delineating the extent of viable tumor tissue for preoperative evaluation of glioma surgery [22][23][24]. This study also found that the most concentrated area for each tracer was sometimes inconsistent in the high-grade gliomas.…”