Discrepancies Between Glycosuria and Home Estimates of Blood Glucose in Insulin-treated Diabetes Mellitus

Ohlsen, P; Danowski, T. S.; Rosenblum, D H; Mreiden, T; Fisher, Eva; Sunder, J. H.

doi:10.2337/diacare.3.1.178

Cited by 28 publications

(5 citation statements)

References 2 publications

(2 reference statements)

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“…Furthermore, because we have used information obtained in normal life, our results are more relevant to the everyday experience of the patients than those achieved on a metabolic ward. We have failed to detect any significant variation of threshold over several months, confirming the original observation of Lawrence 1 and in contrast to the recent work of Ohlsen et al 9 When we applied this type of analysis to results obtained by pregnant women, we have been able to detect changes in threshold during the pregnancy. The technique does therefore seem to be sensitive to such variations when they exist.…”

Section: Resultssupporting

confidence: 71%

The Influence of Renal Threshold on the Interpretation of Urine Tests for Glucose in Diabetic Patients

Walford¹,

Page²,

Allison³

1980

Diabetes Care

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A knowledge of the renal threshold for glucose is important in the interpretation of urine tests in diabetes. We describe a simple method for determining renal threshold from blood and urine tests performed by the patients themselves. In a group of 65 insulin-dependent diabetic patients there was a wide variation in renal threshold, with a mean of 130 mg/dl (range 54-180 mg/dl). Threshold tended to rise with age, and it is suggested that the higher the renal threshold, the higher is the mean blood glucose achieved by the patient (r = 0.50, P = < 0.001). The change in blood glucose required to convert urine tests from 0% to 2% is very variable and ranged from 36 to 288 mg/dl (mean 110 mg/dl). The simple method that we describe may improve understanding of the significance of urine test results without the necessity for hospital admission.

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Section: Resultssupporting

confidence: 71%

The Influence of Renal Threshold on the Interpretation of Urine Tests for Glucose in Diabetic Patients

Walford¹,

Page²,

Allison³

1980

Diabetes Care

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“…24 We did not consider a record of self-determined fractional glycosuria from our patients, because it would be neither reliable nor objective. 25 The average FBS levels in our study were similar to those of other reports of diabetic outpatient clinics, partly reflecting the difficulties in obtaining metabolic normalization with 1526 However, it is to be noted that an U N M E A S diet has been successfully applied in the treatment of type I diabetes designed for tight control with intense insulin therapy. 27 T h e high prevalent mean fasting glycemia and the relatively constant insulin dosages also suggest that more vigorous insulin treatment was needed in this outpatient diabetic population.…”

supporting

confidence: 87%

A Four-year Prospective Trial of Unmeasured Diet In Lean Diabetic Adults

1984

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Fifty-one adult male outpatients at or below ideal body weight (IBW) with no history of weighing more than 15% over IBW in the past 5 yr and no more than 25% in the past 15 yr were randomly assigned to a traditional calorically defined exchange-type diet (EXCH) or an unmeasured diet emphasizing avoidance of refined sugar and balance of food consumption throughout the day. All but 4 patients were insulin treated. With the exception of one patient in each group, all patients were classified as having type II diabetes. Subjects were followed in a single-blind design for 4 yr in the Diabetes Outpatient Clinic every 3 mo. The average mean fasting glycemia (FBS), coefficient of FBS variation, number of reported hypoglycemic reactions, mean fasting serum triglyceride and cholesterol levels, and mean total daily insulin dosage were similar in both groups. Each patient's mean daily caloric intake did vary over time, but there was no difference in mean caloric intake between diet groups. There was a significant correlation between a patient's mean FBS rating and his serum triglyceride level: patients with lower mean FBS had a significantly lower mean triglyceride level than patients with higher FBS. Overall body weights remained stable throughout the study. However, there was a significant difference in the number of patients in the EXCH group whose actual weight was 3% or more above IBW on 50% or more of their visits.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…In addition, scrupulously performed urinary glucose determinations have been demonstrated to be inaccurate as frequently as 60% of the time. 13 ' 14 Hence, glycosuria may not always correlate with blood glucose concentrations or the degree of diabetic control. In contrast, blood glucose monitoring has been shown to give accurate and reliable data that the diabetic patient can use to guide his self-management regimen.…”

Section: Resultsmentioning

confidence: 98%

Evaluation of a New Reflectance Photometer For Use in Home Blood Glucose Monitoring

Clarke¹,

Melton²,

Sachse³

et al. 1981

Diabetes Care

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A new reflectance photometer (Glucometer, Ames Division, Miles Laboratories, Elkhart, Indiana) has been developed for use with the Dextrostix reagent strip. The device measures 8 X 17 cm, weighs 330 g, uses AA batteries, and requires no warm-up. High (330 mg/dl) and low (50 mg/dl) calibrations are stored in memory and need be repeated only when: (1) a control solution (100 mg/dl) reading is in error, (2) ambient temperature changes by more than 5 degrees C, (3) a new bottle of Dextrostix is used, and (4) batteries are changed. A 60-s timer with alarm helps make timing of the procedure consistent. Nineteen insulin-dependent and one non-insulin-dependent diabetic subjects each performed a minimum of 20 blood glucose determinations over a 3-mo period in the investigators' laboratories. Simultaneous capillary blood samples were obtained for plasma glucose analysis by a comparative method. A total of 602 patient-determined glucose values ranging from 30 to 400 mg/dl were compared with simultaneous laboratory values. These values correlated significantly (r = 0.96, P less than 0.0001, y = 2.6 + 0.92x). The Glucometer-Dextrostix System is an accurate and convenient method for home blood glucose monitoring by diabetic patients.

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Discrepancies Between Glycosuria and Home Estimates of Blood Glucose in Insulin-treated Diabetes Mellitus

Cited by 28 publications

References 2 publications

The Influence of Renal Threshold on the Interpretation of Urine Tests for Glucose in Diabetic Patients

The Influence of Renal Threshold on the Interpretation of Urine Tests for Glucose in Diabetic Patients

A Four-year Prospective Trial of Unmeasured Diet In Lean Diabetic Adults

Evaluation of a New Reflectance Photometer For Use in Home Blood Glucose Monitoring

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