Discovery of urinary biomarkers of whole grain rye intake in free‐living subjects using nontargeted LC‐MS metabolite profiling

Hanhineva, Kati; Brunius, Carl; Andersson, Agneta; Marklund, Matti; Juvonen, Risto O.; Keski‐Rahkonen, Pekka; Auriola, Seppo; Landberg, Rikard

doi:10.1002/mnfr.201500423

Cited by 36 publications

(41 citation statements)

References 51 publications

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“…For instance, the changes in their excretion levels are characteristic of whole grain rich diets. It is interesting to note that different studies focusing on whole grain diets have shown either an increase or a decrease in urinary AC concentrations. If the increase suggests the role of AC as potential biomarkers of specific whole rye intake, the decrease in urinary AC is considered to point to changes in lipid metabolism .…”

Section: Discussionmentioning

confidence: 99%

“…It is interesting to note that different studies focusing on whole grain diets have shown either an increase or a decrease in urinary AC concentrations. If the increase suggests the role of AC as potential biomarkers of specific whole rye intake, the decrease in urinary AC is considered to point to changes in lipid metabolism . The authors consider that a whole grain rich diet is associated with a decrease in circulating LDL cholesterol and thus may result in lower urinary excretion of carnitine and AC.…”

Section: Discussionmentioning

confidence: 99%

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Urinary Metabolomics Profiles Associated to Bovine Meat Ingestion in Humans

Khodorova

Rutledge

Oberli

et al. 2018

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Urinary Metabolomics Profiles Associated to Bovine Meat Ingestion in Humans

Khodorova

Rutledge

Oberli

et al. 2018

Molecular Nutrition Food Res

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“…In fact, their metabolized forms have been found in human plasma and urine [26] suggesting that ARs might exert their biological effect in human after whole grain intake. …”

Section: Discussionmentioning

confidence: 99%

Characterization and Discrimination of Ancient Grains: A Metabolomics Approach

Righetti

Rubert

Galaverna

et al. 2016

IJMS

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Hulled, or ancient, wheats were the earliest domesticated wheats by mankind and the ancestors of current wheats. Their cultivation drastically decreased during the 1960s; however, the increasing demand for a healthy and equilibrated diet led to rediscovering these grains. Our aim was to use a non-targeted metabolomic approach to discriminate and characterize similarities and differences between ancient Triticum varieties. For this purpose, 77 hulled wheat samples from three different varieties were collected: Garfagnana T. turgidum var. dicoccum L. (emmer), ID331 T. monococcum L. (einkorn) and Rouquin T. spelta L. (spelt). The ultra high performance liquid chromatography coupled to high resolution tandem mass spectrometry (UHPLC-QTOF) metabolomics approach highlighted a pronounced sample clustering according to the wheat variety, with an excellent predictability (Q2), for all the models built. Fifteen metabolites were tentatively identified based on accurate masses, isotopic pattern, and product ion spectra. Among these, alkylresorcinols (ARs) were found to be significantly higher in spelt and emmer, showing different homologue composition. Furthermore, phosphatidylcholines (PC) and lysophosphatidylcholines (lysoPC) levels were higher in einkorn variety. The results obtained in this study confirmed the importance of ARs as markers to distinguish between Triticum species and revealed their values as cultivar markers, being not affected by the environmental influences.

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“…Using high resolution LC‐MS metabolomics, thousands of small molecule metabolites can be detected in a single analysis of a biological sample, such as urine or blood. In addition to host‐derived physiological metabolites, the resulting metabolomic profile includes compounds derived from the diet, which can serve as biomarkers of specific dietary components . Identification of these metabolites allows for better assessment of compliance in dietary interventions, as well as more robust biomarkers of diet quality .…”

Section: Introductionmentioning

confidence: 99%