Discovery of urease inhibitory effect of sulfamate derivatives: Biological and computational studies

Influence of bridging atoms in copper-based coordination polymers for enhancing urease inhibition activity

“…More importantly, the residues GLN635 and GLY638 are the key amino acids of urease. 32 The binding models also reveal the interactions between the oxygen of μ 2 -OH and the GLN635 of urease, the interactions between the nitrogen groups on the imino of 3-dpye and GLY638 of urease, and the interactions between the oxygen groups of H 2 -BDC and the CME592 of urease (Fig. 6c and d).…”

Triazolothiadiazoles and Triazolothiadiazines as New and Potent Urease Inhibitors: Insights from In Vitro Assay, Kinetics Data, and In Silico Assessment

“…Urease is a popular enzyme in living organisms, responsible for the hydrolysis of urea into carbon dioxide and ammonia. , The high concentrations of ammonia are caused by urease hyperactivity, which leads to a rise in the pH of the stomach, thus resulting in complications like peptic and gastric ulcers, hepatic coma, pyelonephritis, and kidney stones. , This condition of clinical complications demands such inhibitors that can regulate urease activity. ,− Various studies have revealed the diverse variety of compounds such as Schiff base hydrazones, triazole-(thio) barbituric acids, N -thioacylated ciprofloxacin derivatives, and barbituric-hydrazine-phenoxy-1,2,3-triazole-acetamides which possess urease inhibitory effects. − Urease inhibitors have revealed amplification of the urea N uptake in plants and reduction of environmental issues. ,− Additionally, they play a role as strong antiulcer drugs. , …”

“… 9 − 11 12 13 Urease inhibitors have revealed amplification of the urea N uptake in plants 14 and reduction of environmental issues. 6 , 15 − 17 Additionally, they play a role as strong antiulcer drugs. 18 , 19 …”

Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF3SMe2

“…Perhaps the most well-known and earliest reported use of this system is benzyl group cleavage using a combination of boron trifluoride etherate and dimethyl sulfide. The combined boron trifluoride complex has since been used almost exclusively for ether dealkylations. − Some developments toward uses of the complex have nonetheless been accomplished, such as selective cleavage of di- tert- butylsilylene ethers, selective methoxy cleavage, and as a borylation reagent . Recently, we reported BF 3 SMe 2 as a convenient thiomethylating reagent and also showed that it could reduce nitro groups in certain substrates .…”