Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases

Chu, Zhaoxing; Cen, Lifang; Xu, Qinlong; Lin, Gaofeng; Mo, Jiajia; Shao, Li; Zhao, Yan; Li, Jiaming; Ye, Wenfeng; Fang, Tao; Ren, Weijie; Zhu, Qihua; He, Guangwei; Xu, Yungen

doi:10.1016/j.ejmech.2024.116197

European Journal of Medicinal Chemistry

2024

DOI: 10.1016/j.ejmech.2024.116197

|View full text |Cite

Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases

Zhaoxing Chu,

Lifang Cen,

Qinlong Xu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Novel therapeutic receptor agonists and antagonists in allergic conjunctivitis

Abu,

Hehar,

Chigbu

2024

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

Purpose of review Allergic conjunctivitis is characterized by the development of pathophysiological changes to the ocular surface, which occurs when pro-allergic and pro-inflammatory mediators interact with their cognate receptors expressed on immune and nonimmune cells. Traditional treatments with antihistamines and corticosteroids provide relief, but there is a need for more efficacious and tolerable long-term therapy with a better safety profile. This article aims to provide an overview of the mode of action and clinical application of agonist therapies targeting glucocorticoid, melanocortin, and toll-like receptors, as well as antagonist therapies targeting cytokine, chemokine, integrin, and histamine receptors. Recent findings There has been considerable advancement in immunology and pharmacology, as well as a greater understanding of the cellular and molecular mechanisms of allergic conjunctivitis. Recent research advancing therapy for allergic conjunctivitis has focused on developing synthetic molecules and biologics that can interfere with the process of the allergic immune reaction. Summary This review discusses novel therapeutic receptors being explored agonistically or antagonistically to develop alternative treatment options for allergic conjunctivitis. These novel approaches hold promise for improving the management of allergic eye diseases, offering patients hope for more effective and safer treatment options in the future.

show abstract

Novel therapeutic receptor agonists and antagonists in allergic conjunctivitis

Abu,

Hehar,

Chigbu

2024

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases

Cited by 1 publication

References 22 publications

Novel therapeutic receptor agonists and antagonists in allergic conjunctivitis

Novel therapeutic receptor agonists and antagonists in allergic conjunctivitis

Contact Info

Product

Resources

About