Discovery of Potent and Selective c-Met Degraders for Hepatocellular Carcinoma Treatment
Wenjian Min,
Huanaoyu Yang,
Dawei Wang
et al.
Abstract:Targeting c-Met is a clinical trend for the precise treatment of HCC, but the potential issue of acquired drug resistance cannot be ignored. Targeted protein degradation technology has demonstrated promising prospects in disease treatment and overcoming drug resistance due to its special mechanism of action. In this study, we designed and synthesized two series of novel c-Met degraders and conducted a systematic biological evaluation of the optimal compound H11. H11 exhibited good c-Met degradation activity an… Show more
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