Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors

Li, XiaoYang; Wu, Haiwei; Feng, Kai-Wen; Xu, Jiahuan; Wu, Shaoyu; Zhou, Zhong‐Zhen; Li, Xiaofang

doi:10.1016/j.bmc.2022.117007

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…One study showed that intralesional injection of allicin (1 mg) for 16 weeks can significantly improve MMO and BS compared with the control group [ 24 ]. Colchicine reduces collagen synthesis by disrupting microtubule formation and preventing the extrusion of collagen from fibroblasts [ 75 ]. Krishnamoorthy et al [ 76 ] studied the effects of oral administration of 500 mg colchicine and intralesional injection of 0.5 ml hyaluronidase 1,500 IU in the management of OSF and found superior results with colchicine in ameliorating the symptoms of OSF.…”

Section: Discussionmentioning

confidence: 99%

Drug treatment for oral submucous fibrosis: an update

Chen,

Xie,

Guo

2023

BMC Oral Health

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Objective The aim of this review is to evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF). Materials and methods We conducted a comprehensive electronic search on PubMed, Web of Science, and Cochrane Library databases for articles related to OSF patients treated with medications from December 2011 to September 2022. GRADE system was used to evaluate the evidence quality. The reporting of the systematic review is in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The main outcomes were the improvement of maximum mouth opening, burning sensation, cheek flexibility, and tongue protrusion. Results Twenty-nine randomized controlled trials (RCTs), five clinical trials (CCTs) were included, and the use of drugs for OSF treatment were evaluated. Drugs like steroids, hyaluronidase, pentoxifylline, lycopene, curcumin, dpirulina, aloe vera, omega3, oxitard, allicin, colchicine have been used. It was found that drugs with evidence high quality were salvia miltiorrhiza combined with triamcinolone acetonide, lycopene, pentoxifylline, curcumin, and aloe vera, and those with evidence moderate quality were allicin, colchicine, omega 3, and oxitard. Conclusion Based on the results of our comprehensive analysis, for long-term treatment, we found lycopene with low side effects, whereas for relieving the symptoms of severe burning sensation, aloe vera is the most effective. Although the recent review has made some progress, drug therapy for OSF remains unclear, and more high-quality RCTs are needed to identify better treatments for OSF.

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Section: Discussionmentioning

confidence: 99%

Drug treatment for oral submucous fibrosis: an update

Chen,

Xie,

Guo

2023

BMC Oral Health

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“…One study showed that intralesional injection of allicin (1 mg) for 16 weeks can signi cantly improve mouth opening and burning sensation compared with the control group [39]. Colchicine reduces collagen synthesis by disrupting microtubule formation and preventing the extrusion of collagen from broblasts [40]. Krishnamoorthy et al [41] studied the effects of oral administration of 500 mg colchicine and intralesional injection of 0.5 ml hyaluronidase 1,500 IU in the management of OSF and found superior results with colchicine in ameliorating the symptoms of OSF.…”

Section: Other Drugsmentioning

confidence: 99%

Drug treatment for oral submucous fibrosis: a systematic review

Chen

Guo

2023

Preprint

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Objective The aim of this review is to evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF). Materials and methods We searched a comprehensive electronic search on PubMed, Web of Science, and Cochrane Library databases for articles related to OSF patients treated with medications from December 2011 to September 2022. GRADE system was used to evaluate the evidence quality. Results Twenty-nine randomized controlled trials (RCTs), six non-RCT studies were included, and the use of drugs for OSF treatment were evaluated. The main outcomes were improvement in mouth opening, burning sensation, cheek flexibility, and tongue protrusion. Drugs like steroids, hyaluronidase, pentoxifylline, lycopene, curcumin, dpirulina, aloe vera, omega3, oxitard, allicin, colchicine have been used. It was found that drugs with evidence high quality were SMI combined with triamcinolone acetonide, lycopene, pentoxifylline, curcumin, and aloe vera, and those with evidence moderate quality were allicin, colchicine, omega 3, and oxitard. Conclusion Based on the results of our comprehensive analysis, for long-term treatment, we found lycopene with low side effects, whereas for relieving the symptoms of severe burning sensation, aloe vera is the most effective. Although the resent review has made some progress, drug therapy for OSF remains unclear, and more high-quality RCTs are needed to identify better treatments for OSF.

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