Discovery of Pesticide Candidates from Natural Plant Products: Semisynthesis and Characterization of Andrographolide-Based Esters and Study of Their Pesticidal Properties and Toxicology
Meng Hao,
Haixia Ding,
Lulu Li
et al.
Abstract:To explore the use of nonfood plant-derived secondary metabolites for plant protection, a series of ester derivatives for controlling the major migratory agricultural pests were obtained by structural modification of andrographolide, a labdane diterpenoid isolated from Andrographis paniculata. Compound Id showed good insecticidal activity against the fall armyworm Spodoptera frugiperda Smith. Compounds IIa (LC 50 : 0.382 mg/mL) and IIIc (LC 50 : 0.563 mg/mL), the acaricidal activities of which were, respective… Show more
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