Discovery of novel dihydropyrazole-stilbene derivatives for ameliorating heart failure through modulation of p38/NF-κB signaling pathway

Acetic Acid-Catalyzed (3 + 2) Cyclization of 2-Aroyl-3-aryl-1,1-dicyanocyclopropanes with Arylhydrazines: To trans-4-Dicyanomethyl-1,3,5-triaryl-4,5-dihydropyrazoles

“…D ihydropyrazole (pyrazoline) is an important structural unit in many synthetic and naturally occurring compounds which are characterized by a wide spectrum of biological properties (Figure 1) 1 including anticancer, 2 antioxidant, 3 anti-inflammatory, 4 antidiabetic, 5 antimicrobial, 6 antitubercular, 7 antiamoebic, 8 diuretic, 9 and carbonic anhydrase inhibitory, 10 as well as in a heart failure drug. 11 In view of the importance of biologically active dihydropyrazole derivatives, the efficient synthesis of these compounds has received substantial research attention. 12 Among these methods, the most efficient procedure for the synthesis of 4,5dihydropyrazoles is carried out by the cyclization of hydrazine with various electrophiles, including 1,3-dicarbonyl compounds, α,β-unsaturated carbonyls (chalcones) and dihalides.…”

“…Dihydropyrazole (pyrazoline) is an important structural unit in many synthetic and naturally occurring compounds which are characterized by a wide spectrum of biological properties (Figure ) including anticancer, antioxidant, anti-inflammatory, antidiabetic, antimicrobial, antitubercular, antiamoebic, diuretic, and carbonic anhydrase inhibitory, as well as in a heart failure drug …”