Discovery of novel chromone derivatives containing a sulfonamide moiety as potential anti-TSWV agents

Piperazine Derivatives Containing the α-Ketoamide Moiety Discovered as Potential Anti-Tomato Spotted Wilt Virus Agents

“…As shown in Figure , the intermediates a1 – a7 and b1 – b7 were acquired according to the methods previously reported. ,, The intermediates b1 – b7 (5.0 mmol) were dissolved in 10.0 mL of dichloromethane; triethylamine (12.5 mmol) was added in the ice bath; a 10.0 mL dichloromethane solution dissolved with oxalyl monoethyl chloride (7.5 mmol) was slowly added; the ice bath was removed at the end of the feeding; and the reaction at room temperature for 4–5 h obtained the intermediates c1 – c7 . The target compounds 1 – 35 were obtained by an amolysis of esters between c1 and c7 (1.0 mmol) and different primary amines (2.0 mmol) under ethanol reflux.…”

“…19 In the exploration of the mechanism of antiviral drugs, viral coat proteins have always been considered as potential targets, and the interaction between antiviral drugs and viral coat proteins can effectively inhibit the amplification and reproduction of the virus. 8,20,21 Piperazine is a diazepine six-membered heterocyclic ring, whose derivatives are capable of resisting a variety of plant viruses, such as tobacco mosaic virus (TMV), 22−24 cucumber mosaic virus (CMV), 25 potato virus Y (PVY), 26 and tomato chlorosis virus (ToCV). 27 Therefore, on the basis of the previous work, the α-ketoamide structure with good antiviral activity was spliced into the piperazine structure to develop a series of piperazine derivatives containing partial α-ketoamide (Figure 1), 28−30 followed by conducting a bioassay to determine if they were active against TSWV.…”

“…RNP is the core structure and the smallest unit of viral infection in plants and can accelerate the formation of viral RNA and replicate the viral genome into RNA intermediates . In the exploration of the mechanism of antiviral drugs, viral coat proteins have always been considered as potential targets, and the interaction between antiviral drugs and viral coat proteins can effectively inhibit the amplification and reproduction of the virus. ,, …”

Recent Achievements in Antiviral Agent Development for Plant Protection

“…At the same time, the Song’s group also designed and synthesized a number of chromone derivatives containing sulfonamide fragments. Compound 50 had excellent inactivating activity against TSWV with an EC 50 of 80.5 μg/mL, which was much better than vanisulfane (765.7 μg/mL).…”

First Discovery of Novel Cytosine Derivatives Containing a Sulfonamide Moiety as Potential Antiviral Agents

“…Sulfonamides have a broad range of biological activities, like herbicidal, anti-HIV, , anti-fungal, insecticidal, , anti-cancer, and anti-plant virus. − Nucleoside derivatives (or analogues) take an increasingly vital role in medicine and agriculture by influencing the biochemical processes in bacterial or viral cells. For example, cytosine nucleoside and its derivatives have anti-tumor, anti-DNA virus, , anti-hepatitis C virus (HCV), anti-H5N1 type avian influenza virus, anti-cytomegalovirus (HCMV), anti-coxsackie virus (CVB), and anti-TMV activities. − Although sulfonamide and cytosine nucleosides have broad biological activities, the introduction of the sulfonamide moiety into cytosine has not been reported so far.…”