Discovery of NO in the penis

Rajfer, Jacob

doi:10.1038/ijir.2008.10

Cited by 24 publications

(4 citation statements)

References 19 publications

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“…Penile erection (tumescence) and flaccidity (detumescence) are regulated by a complex neurophysiological process involving the relaxation and contraction, respectively, of corpus cavernosum (CC). The principal neurotransmitter for penile erection is nitric oxide (NO), which is released from nonadrenergic, noncholinergic (NANC) neurotransmission of the cavernous nerves and the endothelium [1]. Both constitutively expressed neuronal and endothelial NO synthase (nNOS and eNOS, respectively) isoforms mediate penile erection by producing NO from l ‐arginine.…”

Section: Introductionmentioning

confidence: 99%

Abnormal protein expression in the corpus cavernosum impairs erectile function in type 2 diabetes

Chiou¹,

Liu²,

Juan³

2010

BJU International

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they were then compared with rats that received a normal diet (ND). RESULTSHyperglycaemia and dyslipidaemia were induced in HFD + STZ rats, suggesting that T2D was established. The rats with T2D had associated ED, as both nonadrenergic noncholinergic-mediated corporal relaxation and increased ICP by cavernous nerve stimulation were significantly attenuated compared to the ND group. Western blot analysis revealed diabetes-associated lower expression of endothelial and neuronal nitric oxide synthase (e and nNOS), and cGMPdependent protein kinase (PKG)-1 α / β expression in penile tissue than in the ND group. Contrary to the proteins that regulate corporal relaxation, there were relatively high levels of RhoA/Rho kinase receptor 1 (ROCK1) and ET-A receptor (ETAR) in T2D rats. However, the expressed level of phosphodiesterase-5 and insulin-like growth factor binding protein 3 was not altered significantly in response to T2D. CONCLUSIONDecreased expression of certain proteins that mediate the relaxant mechanism, associated with increased expression of certain proteins that mediate contractile mechanisms, might be important in the development of T2D-associated ED. In particular, down-regulated eNOS/nNOS/ PKG1 as well as up-regulated ETAR/RhoA/ ROCK1 might participate in the aetiology of ED in T2D. KEYWORDS

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Section: Introductionmentioning

confidence: 99%

Abnormal protein expression in the corpus cavernosum impairs erectile function in type 2 diabetes

Chiou¹,

Liu²,

Juan³

2010

BJU International

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“…One theory is that sauna bathing increases nitric oxide (NO) bioactivity [3]. A similar mechanism is also used in ED medication [4]. Therefore, it is worth of investigation if sauna affects erectile function.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols from Prunus armeniaca.L as Promising Anticancer (Cervical Cancer): In silico studies and in vivo safety assessment

2022

AJUN

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Objective: To evaluate a possible effect of Finnish sauna bathing on erectile dysfunction (ED). Materials and Methods: A population-based study was conducted using a mailed questionnaire sent to 5,537 men in 2019. The frequency of sauna bathing was grouped into three categories: once a month or less, once a week and two or more times per week. ED was assessed using the IIEF-5 questionnaire. The questionnaire comprised also items on sociodemographic, medical history; ED and treatment for ED. Chi-square tests and logistic regression analysis were used for statistical analysis. Results: The study cohort included 2,644 men (47.8% response proportion). Frequency of sauna bathing did not affect to IIEF-5 scores (the mean scores for different groups were all close to 20.5) nor to severity of ED. Logistic regression analysis with adjustment for other risk factor showed no association between sauna bathing frequency and ED. Nevertheless, frequency of sexual intercourse was higher among men sauna bathing two or more times per week as mean monthly number of sexual intercourses was 3.5 compared with 2.8-2.5 in the other groups. Other factors than sauna bathing probably explain differences concerning intercourse amounts. There was no statistically significant difference in the use of medication for ED between sauna bathing groups. Conclusions: In our population-based study, sauna bathing does not have effect on ED, although more frequent sauna bathers had more sexual intercourses and had fewer risk factors for ED. Other factors than sauna bathing probably explain differences concerning intercourse amounts.

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Section: Introductionmentioning

confidence: 99%

Untitled

2022

AJUN

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Objective: To evaluate a possible effect of Finnish sauna bathing on erectile dysfunction (ED). Materials and Methods:A population-based study was conducted using a mailed questionnaire sent to 5,537 men in 2019. The frequency of sauna bathing was grouped into three categories: once a month or less, once a week and two or more times per week. ED was assessed using the IIEF-5 questionnaire. The questionnaire comprised also items on sociodemographic, medical history; ED and treatment for ED. Chi-square tests and logistic regression analysis were used for statistical analysis. Results:The study cohort included 2,644 men (47.8% response proportion). Frequency of sauna bathing did not affect to IIEF-5 scores (the mean scores for different groups were all close to 20.5) nor to severity of ED. Logistic regression analysis with adjustment for other risk factor showed no association between sauna bathing frequency and ED. Nevertheless, frequency of sexual intercourse was higher among men sauna bathing two or more times per week as mean monthly number of sexual intercourses was 3.5 compared with 2.8-2.5 in the other groups. Other factors than sauna bathing probably explain differences concerning intercourse amounts. There was no statistically significant difference in the use of medication for ED between sauna bathing groups. Conclusions:In our population-based study, sauna bathing does not have effect on ED, although more frequent sauna bathers had more sexual intercourses and had fewer risk factors for ED. Other factors than sauna bathing probably explain differences concerning intercourse amounts.

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Discovery of NO in the penis

Cited by 24 publications

References 19 publications

Abnormal protein expression in the corpus cavernosum impairs erectile function in type 2 diabetes

Abnormal protein expression in the corpus cavernosum impairs erectile function in type 2 diabetes

Polyphenols from Prunus armeniaca.L as Promising Anticancer (Cervical Cancer): In silico studies and in vivo safety assessment

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