Discovery of new antidepressant agents: In vivo study on Anthemis wiedemanniana Fisch. &amp; Mey

Dereli, Fatma Tuğçe Gürağaç; İlhan, Mert; Akkol, Esra Küpeli

doi:10.1016/j.jep.2018.07.019

Cited by 12 publications

(5 citation statements)

References 46 publications

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“…Animals were accepted inactive when they did not try to escape, except for movements necessary to hold their heads in the water. Five different experimental groups were formed for the evaluation of the effect of each extract and seven experimental groups were used to assess the potential of the fractions [69].…”

Section: Methodsmentioning

confidence: 99%

“…Immobility was measured when the mice did not make any struggle to get rid of the tape for at least 1 min. Four different experimental groups were formed for the evaluation of the effect of each extract and six experimental groups were used to assess the activity of the fractions [69].…”

Section: Methodsmentioning

confidence: 99%

“…The rectal temperature of each mouse was measured with a thermometer 60 min after the injection of tetrabenazine and the temperature changes were calculated. Four different experimental groups were formed for the evaluation the effect of each extract and six experimental groups were used to assess the activity of the fractions [69].…”

Section: Methodsmentioning

confidence: 99%

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Assessment of Antidepressant Effect of the Aerial Parts of Micromeria myrtifolia Boiss. & Hohen on Mice

2019

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The currently available antidepressant agents necessitate the development of newer alternatives because of their serious adverse effects and costs. Traditional medicinal knowledge is likely the key that opens the door to discover new medicines. In Turkish folk medicine, the infusion prepared from aerial parts of Micromeria myrtifolia Boiss. & Hohen is used as pleasure and medicinal tea for its relaxing action. The present research was conceived to confirm the antidepressant’s potential of this traditional medicinal plant. In this process, first of all, the collected and shade-dried aerial parts of M. myrtifolia were powdered and then, extracted using solvents with different polarity as follows; n-hexane, ethyl acetate (EtOAc), and methanol (MeOH). The antidepressant activity of the extracts was evaluated by using several in vivo and in vitro experimental models of depression. When the data obtained from the control and experimental groups were compared, it was determined that the MeOH extract was the most active. The active components of this extract were isolated and identified utilizing various chromatographic separation techniques. The MeOH extract was applied to reversed phase (RP-18) column chromatography to obtain five main fractions and they were tested on antidepressant activity models. The isolated compounds from the obtained fractions were elucidated as rosmarinic acid (1), myricetin (2), apigenin (3), and naringenin (4) which were assumed to be responsible for the antidepressant activity of the aerial parts. According to the results, rosmarinic acid, myricetin, apigenin, and naringenin showed statistically significant activity on forced swimming test and tetrabenazine-induced ptosis models, whereas only rosmarinic acid showed statistically significant activity on the tail suspension test. Apigenin displayed the highest inhibitory activity on MAO A and B enzymes. Studies in the future should be performed to investigate the antidepressant activity mechanism of these natural compounds. The current research could be an important step in the development of the new agents that can be used in the treatment of depression.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Assessment of Antidepressant Effect of the Aerial Parts of Micromeria myrtifolia Boiss. & Hohen on Mice

2019

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“…One hour following co-exposure to Erythrosine and Tartrazine on day 42 between 8:00 am- 11:00 am, rat was individually hanged 50 cm above the floor held firm with a masking tape placed 1 cm approximately away from the tip of the rodent's tail. Immobility or freezing time(s) was taken within 6 min following the previous 4 min delay and the rats were accepted immobile when freeze or when remained stationary and hung passively ( Adebayo et al., 2020 ; Dereli et al., 2018 ).…”

Section: Methodsmentioning

confidence: 99%

Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine

Wopara

Adebayo

Umoren

et al. 2021

Heliyon

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Overuse or overconsumption of food additive or colorant cannot be ignored in our society and there are several reports of it harmful effect on the body system. This study investigated the toxicity effect of tartrazine and erythrosine (ET, 50:50) on neurobehavioral alteration, striatal oxido-nitrosative and pro-inflammatory stress and striatal acetylcholinesterase activity in experimental rat model. Rats were co-exposed to ET (2 mg/kg, 6 mg/kg and 10 mg/kg) and distilled water (control), p.o for 6 weeks. The change in neurobehavioral function (Open field test, Forced swimming test and Tail suspension test), Lipid peroxidation (Malonaldehyde, MDA), Antioxidants (Glutathione, GSH; Catalase, CAT) Nitrite, Pro-inflammatory cytokine (Tumor necrosis factor-alpha, TNF-α) and Acetylcholinesterase (AChE) activity were evaluated. Results showed significant decrease in neurobehavioral functions after co-exposure to ET. Moreover, there were significant increase in MDA and Nitrite level, significant decrease in the concentration of GSH and CAT and a significant increase TNF-α concentration and AChE activity after co-exposure to ET. Oral co-exposure to tartrazine and erythrosine induced decrease in locomotion and exploration, increase anxiety and depression-like behavior and altered the cholinergic system through upregulation of oxido-nitrosative stress, pro-inflammatory cytokine and acetylcholinesterase activity.

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“…They are attributed to the pharmacological properties of a variety of medicinal plants ( de Las Heras and Hortelano, 2015 ). They have analgesic, anti-inflammatory, anti-insomnia, antidepressant, anxiolytic, skin penetration enhancement, antiviral, antifungal, antibacterial, antiparasitic, cancer chemoprevention, and antihyperglycemic activities ( Paduch et al, 2007 ; Gürağaç et al, 2018 ; Gürağaç Dereli et al, 2020 ; Gürağaç Dereli et al, 2020 ).…”

Section: Natural Compounds and The Affected Pathways In Similar Waysmentioning

confidence: 99%

Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases

et al. 2021

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Psychiatric disorders are frequently encountered in many neurological disorders, such as Alzheimer’s and Parkinson diseases along with epilepsy, migraine, essential tremors, and stroke. The most common comorbid diagnoses in neurological diseases are depression and anxiety disorders along with cognitive impairment. Whether the underlying reason is due to common neurochemical mechanisms or loss of previous functioning level, comorbidities are often overlooked. Various treatment options are available, such as pharmacological treatments, cognitive-behavioral therapy, somatic interventions, or electroconvulsive therapy. However oral antidepressant therapy may have some disadvantages, such as interaction with other medications, low tolerability due to side effects, and low efficiency. Natural compounds of plant origin are extensively researched to find a better and safer alternative treatment. Experimental studies have shown that phytochemicals such as alkaloids, terpenes, flavonoids, phenolic acids as well as lipids have significant potential in in vitro and in vivo models of psychiatric disorders. In this review, various efficacy of natural products in in vitro and in vivo studies on neuroprotective and their roles in psychiatric disorders are examined and their neuro-therapeutic potentials are shed light.

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Discovery of new antidepressant agents: In vivo study on Anthemis wiedemanniana Fisch. & Mey

Cited by 12 publications

References 46 publications

Assessment of Antidepressant Effect of the Aerial Parts of Micromeria myrtifolia Boiss. & Hohen on Mice

Assessment of Antidepressant Effect of the Aerial Parts of Micromeria myrtifolia Boiss. & Hohen on Mice

Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine

Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases

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