Discovery of New 2-Phenylamino-3-acyl-1,4-naphthoquinones as Inhibitors of Cancer Cells Proliferation: Searching for Intra-Cellular Targets Playing a Role in Cancer Cells Survival
Abstract:A series of 2-phenylamino-3-acyl-1,4-naphtoquinones were evaluated regarding their in vitro antiproliferative activities using DU-145, MCF-7 and T24 cancer cells. Such activities were discussed in terms of molecular descriptors such as half-wave potentials, hydrophobicity and molar refractivity. Compounds 4 and 11 displayed the highest antiproliferative activity against the three cancer cells and were therefore further investigated. The in silico prediction of drug likeness, using pkCSM and SwissADME explorer … Show more
“…Benzoquinone derivatives are commonly found in natural products and have been widely studied as antioxidant agents in the struggle against different diseases. 1–6 These compounds comprise a six-membered ring where two hydrogen atoms have replaced by two oxygens. In a simple form, they can be interpreted as derivatives of hydroquinone, catechol, and resorcinol, where the O–H bond is broken due to a homolytic cleavage.…”
The electronic structure, changes in aromatic behavior, and stability of the m-quinone, the least studied member of the benzoquinone family, have been analyzed.
“…Benzoquinone derivatives are commonly found in natural products and have been widely studied as antioxidant agents in the struggle against different diseases. 1–6 These compounds comprise a six-membered ring where two hydrogen atoms have replaced by two oxygens. In a simple form, they can be interpreted as derivatives of hydroquinone, catechol, and resorcinol, where the O–H bond is broken due to a homolytic cleavage.…”
The electronic structure, changes in aromatic behavior, and stability of the m-quinone, the least studied member of the benzoquinone family, have been analyzed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.