Discovery of Natural Multi‐Target Neuraminidase Inhibitors Anti‐Influenza Virus from Chinese Medicinal Herbs Containing Coumarin: In Silico and In Vitro Experiments
Yidi Wu,
Jiamin Hu,
Bei Ma
et al.
Abstract:During in silico research, based on molecular docking, dynamics simulation, network pharmacology and ADMET (absorption, distribution, metabolism, excretion, and toxicity) property, 31 potential compounds are obtained from seven Chinese medicinal herbs containing coumarins. Moreover, mechanism researches discover these compounds treat influenza A virus through key targets TLR4, MMP9, and IL6 (high fever, acute respiratory distress syndrome), MAPK1 and MAPK3 (MAPK signaling pathway, viral RNP export and viral pr… Show more
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