Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics

Goto, Yamato; Iwata, Seigo; Miyahara, Masaya; Miyako, Eijiro

doi:10.1002/advs.202301679

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…However, it is not responses and promote immune memory, significantly prolonging survival. 67 Simultaneously, this combined complex of ITM and purple photosynthetic bacteria may diagnose tumors, making it a therapeutic diagnostic agent for use in highly targeted immune elimination of tumors and precise labeling of tumor locations. 67 4.…”

Section: Exploration and Controversies In The Early Diagnosis Of Itm ...mentioning

confidence: 99%

“…67 Simultaneously, this combined complex of ITM and purple photosynthetic bacteria may diagnose tumors, making it a therapeutic diagnostic agent for use in highly targeted immune elimination of tumors and precise labeling of tumor locations. 67 4. The specificity of the ITM to monitor tumors may be improved.…”

Section: Exploration and Controversies In The Early Diagnosis Of Itm ...mentioning

confidence: 99%

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The value of intratumoral microbiota in the diagnosis and prognosis of tumors

Zhou,

Zhang,

Fan

et al. 2024

Cell Biochemistry & Function

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Intratumoral microbiota (ITM) are microorganisms present in tumor cells. ITM participate in tumor development by affecting tumor cells directly and the tumor microenvironment (TME), indirectly. Alterations in ITM instigate changes in tumor DNA, activate oncogenic pathways, induce tumor inflammatory responses, disrupt normal immune activity, and facilitate the secretion of effectors leading to tumor progression, metastasis, or diminished therapeutic effects. ITM varies significantly in different types of cancer cells and disease states. The presence of certain ITM serves as a predictor of various disease states. Thus, ITM predicts tumorigenesis, tumor grade, treatment efficacy, and prognosis, making it a potential tumor biomarker. The present study aimed to determine the mechanisms by which ITM affects tumor development, especially through the TME; highlight the significant potential of ITM in enhancing tumor diagnosis and prognosis; and outline future directions for ITM research, with a focus on the development of innovative tumor markers.

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Section: Exploration and Controversies In The Early Diagnosis Of Itm ...mentioning

confidence: 99%

Section: Exploration and Controversies In The Early Diagnosis Of Itm ...mentioning

confidence: 99%

The value of intratumoral microbiota in the diagnosis and prognosis of tumors

Zhou,

Zhang,

Fan

et al. 2024

Cell Biochemistry & Function

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“…Tumor‐resident microbiota showed great tumor‐homing potential; thus, they could be potentially tumor‐targeting weapons. Some bacteria isolated from the tumors showed preferential growth and proliferation within a targeted tumor milieu, and effectively caused immune cells to infiltrate the tumor and provoked strong anti‐cancer responses in various syngeneic mouse models 168 . Similar effect was also used to generate bacteria with intratumoral release of nanobodies targeting PD‐L1 and CTLA‐4, and administration of the bacteria showed enhanced therapeutic response 169 .…”

Section: Exploiting the Intratumor Microbiome As Therapeutic Targetsmentioning

confidence: 99%

Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology

Jiang,

Yang,

Dai

et al. 2023

MedComm

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The polymorphic microbiome has been proposed as a new hallmark of cancer. Intratumor microbiome has been revealed to play vital roles in regulating tumor initiation and progression, but the regulatory mechanisms have not been fully uncovered. In this review, we illustrated that similar to other components in the tumor microenvironment, the reside and composition of intratumor microbiome are regulated by tumor cells and the surrounding microenvironment. The intratumor hypoxic, immune suppressive, and highly permeable microenvironment may select certain microbiomes, and tumor cells may directly interact with microbiome via molecular binding or secretions. Conversely, the intratumor microbiomes plays vital roles in regulating tumor initiation and progression via regulating the mutational landscape, the function of genes in tumor cells and modulating the tumor microenvironment, including immunity, inflammation, angiogenesis, stem cell niche, etc. Moreover, intratumor microbiome is regulated by anti‐cancer therapies and actively influences therapy response, which could be a therapeutic target or engineered to be a therapy weapon in the clinic. This review highlights the intratumor microbiome as a vital component in the tumor microenvironment, uncovers potential mutual regulatory mechanisms between the tumor microenvironment and intratumor microbiome, and points out the ongoing research directions and drawbacks of the research area, which should broaden our view of microbiome and enlighten further investigation directions.

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“…Thanks to the technological boosts in large-scale sequencing over the past decade, multiple databases of the gut microbiome have been built to examine these functions(Table 1). These functions are related to the pathological processes of many human diseases, especially the development, progression, and immune evasion of cancer, as well as the modulatory effects of cancer treatments [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Critical role of the gut microbiota in immune responses and cancer immunotherapy

Li,

Xiong,

Liang

et al. 2024

J Hematol Oncol

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The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there has been accumulating evidence of the connections between the gut microbiota and cancer immunotherapy. Therefore, understanding the functional role of the gut microbiota in regulating immune responses to cancer immunotherapy is crucial for developing precision medicine. In this review, we extract insights from state-of-the-art research to decipher the complicated crosstalk among the gut microbiota, the systemic immune system, and immunotherapy in the context of cancer. Additionally, as the gut microbiota can account for immune-related adverse events, we discuss potential interventions to minimize these adverse effects and discuss the clinical application of five microbiota-targeted strategies that precisely increase the efficacy of cancer immunotherapy. Finally, as the gut microbiota holds promising potential as a target for precision cancer immunotherapeutics, we summarize current challenges and provide a general outlook on future directions in this field.

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Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics

Cited by 7 publications

References 41 publications

The value of intratumoral microbiota in the diagnosis and prognosis of tumors

The value of intratumoral microbiota in the diagnosis and prognosis of tumors

Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology

Critical role of the gut microbiota in immune responses and cancer immunotherapy

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