2022
DOI: 10.1007/s00404-022-06686-y
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Discovery of immune-related diagnostic biomarkers and construction of diagnostic model in varies polycystic ovary syndrome

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Cited by 9 publications
(6 citation statements)
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“…As an IL6R ligand, IL6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays important role in immune response.IL6R has been studied to be correlated with PCOS. The research found between PCOS patients and normal individuals, the most observed in ammation status of IL6R has been resulted from relative obesity or insulin resistance, and meanwhile not independent character of PCOS 35,36 . The IL6R difference in NA and HA PCOS has not been reported.…”
Section: Further Validation For New Na Pcos and Ha Pcos Markersmentioning
confidence: 86%
“…As an IL6R ligand, IL6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays important role in immune response.IL6R has been studied to be correlated with PCOS. The research found between PCOS patients and normal individuals, the most observed in ammation status of IL6R has been resulted from relative obesity or insulin resistance, and meanwhile not independent character of PCOS 35,36 . The IL6R difference in NA and HA PCOS has not been reported.…”
Section: Further Validation For New Na Pcos and Ha Pcos Markersmentioning
confidence: 86%
“…Studies have stated that hormone abnormalities in PCOS can overstimulate the immune system, and concurrently, inflammatory cell infiltration aggravates ovarian dysfunction and metabolic disorders [ 35 , 36 ]. High infiltrating abundances of macrophages [ 37 ], neutrophils, activated dendritic cells [ 38 ], and eosinophils [ 39 , 40 ] were observed in PCOS. Since chronic low-level inflammation plays a critical role in PCOS [ 41 ], we investigated and compared the immune infiltration and cytokine levels in different groups.…”
Section: Discussionmentioning
confidence: 99%
“…GO term and pathway enrichment analysis showed that DEGs were highly enriched in the present investigation, which undoubtedly verifies the reliability of our results. Signaling pathways include cytokine signaling in immune system [48], extracellular matrix organization [49], diseases of metabolism [50], hemostasis [51], innate immune system [52], metabolism of lipids [53] and metabolism [54] were linked with progression of PCOS. Altered expression of PLA2G5 [55], CASP1 [56], EDNRA (endothelin receptor type A) [57], F2RL1 [58], FOXP3 [59], DRD4 [60], COL6A3 [61], TIMP4 [62], SOCS1 [63], CD74 [64], TGFB1 [65], ATF5 [66], IRF7 [67], IRX3 [68], FOXC2 [69], STX1A [70], IL1RL1 [71], HHIP (hedgehog interacting protein) [72], ELOVL2 [73], BGN (biglycan) [74], POMC (proopiomelanocortin) [75], DOK5 [76], COL1A1 [77], POSTN (periostin) [78], SOD3 [79], ZNF423 [80], FABP5 [81], DDIT4 [82], KCTD15 [83], COL1A2 [84], MGAT2 [85], ENDOG (endonuclease G) [86], HSPA5 [87], CES1 [88], CYP19A1 [89], PLAC8 [90], CD36 [91], GIPR (gastric inhibitory polypeptide receptor) [92], ARG1 [93], MSR1 [94], DOCK2 [95], S1PR1 [96], OXTR (oxytocin receptor) [97], F11R [98], LEPR (leptin receptor) [99], AR (androgen receptor) [100], DKK3 [101], FOXO1 [102], PIK3CB [103], WWP1 [104], PHIP (pleckstrin homology domain interacting protein) [105], MPZL3 [106], FBXO2 [107], GUCY2C [108], ADRA2A [109], CHRNA5 [110], GLP2R [111], SDC3 [112], NFAT5 [113], PON2 [114], PRNP (prion protein) [115], DGKE (diacylglycerol kinase epsilon) [116], AR...…”
Section: Discussionmentioning
confidence: 99%