Abstract:The serine protease inhibitor Rv3364c
of Mycobacterium
tuberculosis (MTB) is highly expressed in cells during
MTB exposure. In this study, we showed that the 12WLVSKF17 motif of Rv3364c interacts with the BAR domain of SNX9 and
inhibits endosome trafficking to interact with p47phox, thereby suppressing
TLR4 inflammatory signaling in macrophages. Derived from the structure
of this Rv3364c peptide motif, 2,4-diamino-6-(4-tert-butylphenyl)-1,3,5-trazine, DATPT as a 12WLVSKF17 peptide-mimetic small molecule has be… Show more
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