Discovery of highly functionalized grayanane diterpenoids from the flowers of Rhododendron molle as potent analgesics

Zheng, Guijuan; Huang, Lang; Feng, Yuanyuan; Zhang, Hanqi; Gao, Biao; Ma, Xiaomin; Sun, Yenan; Abudurexiti, Adila; Yao, Guangmin

doi:10.1016/j.bioorg.2023.106928

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Compounds 14, 15, 19-22, and 24-25 exhibited significant antinociceptive effects at 5 mg/kg, surpassing 50% inhibition using morphine as a positive control in the acetic acid-induced writhing test. Zhou et al reported eight novel diterpenes compounds (26)(27)(28)(29)(30)(31)(32)(33) from the leaves of R. molle [9]. Additionally, Zhu et al identified seven new diterpenes (34)(35)(36)(37)(38)(39) from the leaves and twigs of R. decorum [25], with compounds 34, and 36-39 displaying significant antinociceptive activity at 10 mg/kg.…”

Section: Overview Of Structural Diversity and Biological Activities O...mentioning

confidence: 99%

“…Among compounds 84-86, purified from the leaves of C. yunnanense [31], 84 and 85 displayed significant anti-inflammatory activity, particularly inhibiting IL-6 release in lipopolysaccharide (LPS)-induced RAW264.7 cells. Zheng et al identified six new diterpenes (87-92) from the flowers of R. molle as potent analgesics [32]. Notably, compound 92 demonstrated remarkable activity, remaining effective even at the dose of 0.04 mg/kg in vivo pain assay screenings.…”

Section: Overview Of Structural Diversity and Biological Activities O...mentioning

confidence: 99%

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Recent Advances in Grayanane Diterpenes: Isolation, Structural Diversity, and Bioactivities from Ericaceae Family (2018–2024)

Liu,

Sun,

Zhang

et al. 2024

Molecules

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Diterpenes represent one of the most diverse and structurally complex families of natural products. Among the myriad of diterpenoids, grayanane diterpenes are particularly notable. These terpenes are characterized by their unique 5/7/6/5 tetracyclic system and are exclusive to the Ericaceae family of plants. Renowned for their complex structures and broad spectrum of bioactivities, grayanane diterpenes have become a primary focus in extensive phytochemical and pharmacological research. Recent studies, spanning from 2018 to January 2024, have reported a series of new grayanane diterpenes with unprecedented carbon skeletons. These compounds exhibit various biological properties, including analgesic, antifeedant, anti-inflammatory, and inhibition of protein tyrosine phosphatase 1B (PTP1B). This paper delves into the discovery of 193 newly identified grayanoids, representing 15 distinct carbon skeletons within the Ericaceae family. The study of grayanane diterpenes is not only a deep dive into the complexities of natural product chemistry but also an investigation into potential therapeutic applications. Their unique structures and diverse biological actions make them promising candidates for drug discovery and medicinal applications. The review encompasses their occurrence, distribution, structural features, and biological activities, providing invaluable insights for future pharmacological explorations and research.

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Section: Overview Of Structural Diversity and Biological Activities O...mentioning

confidence: 99%

Section: Overview Of Structural Diversity and Biological Activities O...mentioning

confidence: 99%

Recent Advances in Grayanane Diterpenes: Isolation, Structural Diversity, and Bioactivities from Ericaceae Family (2018–2024)

Liu,

Sun,

Zhang

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

Dauresorcinols A and B, two pairs of merosesquiterpenoid enantiomers with new carbon skeletons from Rhododendron dauricum

Zhang,

Gao,

Zheng

et al. 2024

Bioorganic Chemistry

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Structurally diverse analgesic diterpenoids from the flowers of Rhododendron molle

Zheng,

Huang,

Feng

et al. 2024

Fitoterapia

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Discovery of highly functionalized grayanane diterpenoids from the flowers of Rhododendron molle as potent analgesics

Cited by 3 publications

References 38 publications

Recent Advances in Grayanane Diterpenes: Isolation, Structural Diversity, and Bioactivities from Ericaceae Family (2018–2024)

Recent Advances in Grayanane Diterpenes: Isolation, Structural Diversity, and Bioactivities from Ericaceae Family (2018–2024)

Dauresorcinols A and B, two pairs of merosesquiterpenoid enantiomers with new carbon skeletons from Rhododendron dauricum

Structurally diverse analgesic diterpenoids from the flowers of Rhododendron molle

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