Discovery of Green Tea Polyphenol-Based Antitumor Drugs: Mechanisms of Action and Clinical Implications

Ahmed, Reda Saber Ibrahim; Soave, Claire; Edbauer, Tracey Guerin; Patel, Kush; Elghoul, Yasmine; Oliveira, Antonio Vinicius Pazetti de; Renzetti, Andrea; Foldes, Robert L.; Chan, T. H.; Dou, Q. Ping

doi:10.1007/978-3-030-31269-5_14

Cited by 3 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High doses of EGCG in rat ELT3 UF cells significantly inhibited cell growth, leading to a 40% decrease in proliferation and reduced the expressions of proliferation markers like PCNA and CDK4 proteins. Pro-EGCG analogs have shown promise in inhibiting proteasome and Akt signaling pathways [ 75 ]. EGCG also inhibits the production and activity of pro-inflammatory molecules, mitigating the inflammatory response associated with UF growth.…”

Section: Optimal Dietary Choices To Consider (Food Modifications)mentioning

confidence: 99%

Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness

Vafaei,

Alkhrait,

Yang

et al. 2024

Nutrients

View full text Add to dashboard Cite

Uterine fibroids (UFs) are the most common prevalent benign tumor among women of reproductive age, disproportionately affecting women of color. This paper introduces an innovative management strategy for UFs, emphasizing the curbing of disease prevention and progression. Traditionally, medical intervention is deferred until advanced stages, necessitating invasive surgeries such as hysterectomy or myomectomy, leading to high recurrence rates and increased healthcare costs. The strategy, outlined in this review, emphasizes UF disease management and is named LIFE UP awareness—standing for Lifestyle Interventions, Food Modifications, and Environmental Practices for UF Prevention. These cost-effective, safe, and accessible measures hold the potential to prevent UFs, improve overall reproductive health, reduce the need for invasive procedures, and generate substantial cost savings for both individuals and healthcare systems. This review underscores the importance of a proactive UF management method, paving the way for future research and policy initiatives in this domain.

show abstract

Section: Optimal Dietary Choices To Consider (Food Modifications)mentioning

confidence: 99%

Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness

Vafaei,

Alkhrait,

Yang

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Treatment with EGCG led to a 40% decrease in cell proliferation at 72 h along with significant reduction of proliferation markers expression such as proliferating cell nuclear antigen (PCNA) and cyclin-dependent kinases (CDKs)-4 proteins [143,144]. According to a study by Ahmed et al, the Pro-EGCG analogs 2a and 4a reduced susceptibility to COMT-mediated methylation and were found to inhibit proteasome and Akt signaling pathways [145]. EGCG significantly lowered the concentration of curcumin required to inhibit the AKT-mTOR pathway, reduce cell proliferation and induce apoptosis in uterine LMS cells by enhancing intracellular incorporation of curcumin [146].…”

Section: Epigallocatechin Gallate (Egcg) and Green Tea Extract Consum...mentioning

confidence: 99%

Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach)

Vafaei,

Ciebiera,

Omran

et al. 2023

IJMS

View full text Add to dashboard Cite

Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives patients of good quality of life (QOL). Unfortunately, even if the disease is discovered early, no medical intervention is traditionally initiated until the disease burden becomes high, and only then is surgical intervention performed. Furthermore, after myomectomy, the recurrence rate of UFs is extremely high with the need for additional surgeries and other interventions. This confused approach is invasive and extremely costly with an overall negative impact on women’s health. Secondary prevention is the management of early disease to slow down its progression or even halt it completely. The current approach of watchful observation for early disease is considered a major missed opportunity in the literature. The aim of this article is to present an approach named the ESCAPE (Evidence-Based Approach for Secondary Prevention) of UF management. It comprises simple, inexpensive, and safe steps that can arrest the development of UFs, promote overall reproductive health, decrease the number of unnecessary surgeries, and save billions of health care systems’ dollars worldwide.

show abstract

Medicinal Plants Domestication, Cultivation, Improvement, and Alternative Technologies for the Production of High Value Therapeutics: An Overview

Ramawat

Arora

2021

Sustainable Development and Biodiversity

View full text Add to dashboard Cite

Discovery of Green Tea Polyphenol-Based Antitumor Drugs: Mechanisms of Action and Clinical Implications

Cited by 3 publications

References 54 publications

Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness

Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness

Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach)

Medicinal Plants Domestication, Cultivation, Improvement, and Alternative Technologies for the Production of High Value Therapeutics: An Overview

Contact Info

Product

Resources

About