Discovery of Bispecific Lead Compounds From Azadirachta Indica Against ZIKA NS2B-NS3 Protease and RNA Dependent RNA Polymerase Using Molecular Simulations
Abstract:Zika virus (ZIKV) has been characterized as one of the potential pathogens and placed under future epidemic outbreaks by the WHO. However, lack of potential therapeutics can result in uncontrolled pandemic like other human pandemic viruses; therefore, prioritized effective therapeutics development has been recommended against ZIKV. In this context, the present study adopted the strategy to explore the lead compounds from Azadirachta indica against ZIKV via concurrent inhibition of the ZIKVpro and ZIKVRdRp prot… Show more
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