Discovery of anti-inflammatory terpenoids from Mallotus conspurcatus croizat

Zhang, Yanjun; Huang, Xishan; Chen, Huangcan; Zhou, Dexiong; Yang, Zhengmin; Wang, Ke; Liu, Wei; Deng, Shengping; Yang, Ronghua; Li, Jun; He, Ruijie

doi:10.1016/j.jep.2018.11.002

Cited by 14 publications

(7 citation statements)

References 27 publications

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“…Compared to the relevant literature which has been reported, the structures of the isolated compounds have been established on the basis of 1 H‐NMR, 13 C‐NMR spectra. These compounds were recorded as follows: apigenin ( 1 ), [12] genistin ( 2 ), [7] 5,7,4‐trihydroxyisoflavone‐5‐O‐ β ‐D‐glucopyranoside ( 3 ), [13] 5,7,3′‐trihydroxy‐4‐methoxyisoflavone‐7‐O‐ β ‐lucopyranoside ( 4 ), [14] a ‐ionol ( 5 ), [15] kaemferitrin ( 6 ), [16] 1 H ‐indole‐3‐carboxylic acid ( 7 ), [17] p ‐hydroxybenzoic acid ( 8 ), [18] trans ‐ p ‐hydroxycinnamic acid ( 9 ), [19] cis‐p‐ hydroxycinnamic acid ( 10 ), [20] methyl trans‐ 4‐hydroxycinnamate ( 11 ), [21] scopoletin ( 12 ), [19] daucosterol ( 13 ), [21] β ‐sitosterol ( 14 ), [22] uracil ( 15 ), [23] 6‐hydroxypurine ( 16 ), [24] 9‐ribofuranosyladenine ( 17 ) [25] . Figure 1 shows structures of compounds 1 – 17 isolated from L. bulbifera .…”

Section: Resultsmentioning

confidence: 99%

“…Five phenolic acids, one terpenoid, one coumarin, two steroids, three alkaloids (5 and 7 -17) have a wide distribution in lots of families. In addition, nine compounds (8 -15 and 17) were reported previously from genus Urtica, [15,[17][18][19][20][21] which might demonstrate the close relationship between the genera Laportea and Urtica.…”

Section: Chemotaxonomic Significancementioning

confidence: 99%

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Phytochemical, Chemotaxonomic and Bioinformatics Study on Laportea bulbifera (Urticaceae)

Zhao

et al. 2022

Chemistry & Biodiversity

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Phytochemical investigation of the aerial part of Laportea bulbifera (Siebold & Zucc.) Wedd. (L. bulbifera) showed the isolation of seventeen compounds, including five flavonoids (1–4 and 6), one terpenoid (5), five phenolic acids (7–11), one coumarin (12), two steroids (13–14), and three alkaloids (15–17). Structure elucidations of these compounds were performed on the basis of extensive NMR experiments and compared with the published data in the references. It is remarkable that compounds (3–5) were firstly isolated from the Urticaceae family, compounds (3–8, 11 and 15–17) were firstly obtained from genus Laportea. Furthermore, the result of the chemotaxonomic significance discussion showed that compounds (2–4) may can be served as compound fingerprints to distinguish between species of L. bulbifera and genus Urtica, and what’ more, we proposed a bold conjecture that isoflavones can distinguish between species of L. bulbifera and genus Urtica. At the same time, the molecular docking method was used to evaluate the inhibitory effect of these compounds on human steroid 5α‐reductase 2 (SRD5α2). The results showed that compounds (1–4 and 6) had better expected effects than the positive drug finasteride can by effectively binding to the active sites of SRD5α2. This study assisted in the future phytochemical and chemotaxonomic research on genus Laportea. Simultaneously, this research provided the theoretical evidence for the application of L. bulbifera in treating benign prostatic hyperplasia (BPH).

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Section: Resultsmentioning

confidence: 99%

Section: Chemotaxonomic Significancementioning

confidence: 99%

Phytochemical, Chemotaxonomic and Bioinformatics Study on Laportea bulbifera (Urticaceae)

Zhao

et al. 2022

Chemistry & Biodiversity

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“…In another study, glycyrrhetinic acid confirmed its effect on CVD by decreasing PL in serum, FFA, VLDL-c, LDL-c, TG, TC, and BG, and increasing HLD-c, insulin, and Hb [ 110 , 111 ]. Terpenoids can control the effect of cardiovascular disease as natural inhibitors of NF- κ B, which can inhibit the NF- κ B signalling pathway through I κ B phosphorylation, DNA binding, and p65 translocation [ 112 , 113 ]. Artemisinin is found naturally in Artemisia annua and has anti-inflammatory properties through blocking NF-B activation [ 114 , 115 ].…”

Section: Plant-derived Phytochemicals In Prevention and Treatment Of Cvdmentioning

confidence: 99%

Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review

Bachheti

Abate

Gonfa

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Cardiovascular diseases (CVDs) are the world’s leading killers, accounting for 30% deaths. According to the WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 million deaths from CVD in 2030. The death rates rise as people get older. Regarding gender, the death rate of women by CVD (51%) is higher than that of men (42%). To decrease and prevent CVD, most people rely on traditional medicine originating from the plant (phytochemicals) in addition to or in preference to commercially available drugs to recover from their illness. The CVD therapy efficacy of 92 plants, including 15 terrestrial plants, is examined. Some medicinal plants well known to treat CVD are, Daucus carota, Nerium oleander, Amaranthus Viridis, Ginkgo biloba, Terminalia arjuna, Picrorhiza kurroa, Salvia miltiorrhiza, Tinospora cordifolia, Mucuna pruriens, Hydrocotyle asiatica, Bombax ceiba, and Andrographis paniculate. The active phytochemicals found in these plants are flavonoids, polyphenols, plant sterol, plant sulphur compounds, and terpenoids. A general flavonoid mechanism of action is to prevent low-density lipoprotein oxidation, which promotes vasodilatation. Plant sterols prevent CVD by decreasing cholesterol absorption in the blood. Plant sulphur compound also prevent CVD by activation of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and inhibition of cholesterol synthesis. Quinone decreases the risk of CVD by increasing ATP production in mitochondria while terpenoids by decreasing atherosclerotic lesion in the aortic valve. Although several physiologically active compounds with recognized biological effects have been found in various plants because of the increased prevalence of CVD, appropriate CVD prevention and treatment measures are required. More research is needed to understand the mechanism and specific plants’ phytochemicals responsible for treating CVD.

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“…Zhang et al. 95 isolated and evaluated the ethyl acetate fraction of the ethanol extract from Mallotus conspurcatus croizat, and found two new terpenoids 146 and 147 , both of which demonstrated marked suppression of the secretion of PGE 2 and the expression of TNF- α , iNOS, NF- κ B, and COX-2 proteins. Three new sesquiterpenoids 148 , 149 , and 150 were isolated from the rhizomes and roots of Nardostachys jatamansi ( Fig.…”

Section: Chemistry and Pharmacology Of Structurally Modified Cox-2 In...mentioning

confidence: 99%

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

Zhang

et al. 2022

Acta Pharmaceutica Sinica B

122

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Discovery of anti-inflammatory terpenoids from Mallotus conspurcatus croizat

Cited by 14 publications

References 27 publications

Phytochemical, Chemotaxonomic and Bioinformatics Study on Laportea bulbifera (Urticaceae)

Phytochemical, Chemotaxonomic and Bioinformatics Study on Laportea bulbifera (Urticaceae)

Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

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