Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors

Cathelicidin peptide analogues inhibit EV71 infection through blocking viral entry and uncoating

“…We next explored whether LL-18 or FF-18 affects viral attachment and internalization. The aminothiazole derivative (12 s ), a small molecule compound reported to inhibit EV71 by interfering with viral VP1-SCARB2 interaction [ 18 ], was used as a positive control. EV71 viruses were pre-incubated with PBS, 12s, LL-18, or FF-18 and then incubated with RD cells at 4°C for 1 hr to allow virus attachment to host cells.…”

Plant Viral Coat Proteins as Biochemical Targets for Antiviral Compounds

“…Coat proteins are also key antiviral therapeutic targets for many human viruses that infect humans, such as enterovirus A71, enterovirus D68, hepatitis B virus (HBV), and human immunodeficiency virus (HIV). Many compounds have been designed to target viral proteins: 3-(4-Pyridyl)-2-imidazolidinone derivatives (GPP3, EC 50 10 nM), licochalcone A (EC 50 9.30 μM), and aminothiazole derivatives (e.g., 12s , EC 50 0.27 μM) have been designed and synthesized using the enterovirus A71 CP as the target. − Pyrazolopyridine analogues (e.g., 7a , EC 50 16.7 μM) are antiviral compounds targeting the enterovirus D68 CP . Heteroaryldihydropyrimidines (e.g., GLS4, EC 50 0.012 mM) are antiviral drugs that target the HBV CP and induce aberrant self-assembly, and GS-6207 (EC 50 105 pM) is an HIV replication inhibitor that targets the HIV-1 CP …”

“…CMV CP Inhibitors. DNPE6(11), a homogeneous heteropolysaccharide (EC 50 402.4 ± 2.0 μg/mL) extracted from Dendrobium nobile Lindl., has superior antiviral potency against CMV in comparison with chitosan oligosaccharide and lentinan. 66 DNPE6 (…”