“…Reasonably, in this study, we used a pyrrolyl ring with different substituents such as isosteres to replace the furyl ring and investigate their effects on activity. - The imidazolyl group is an important functional fragment with two nitrogen atoms and is widely present in numerous biomolecules, like histidine and histamine, as well as in antifungal drugs. Its unique structure easily binds with various biological targets through noncovalent interactions, which can overcome drug resistance, improve bioavailability and biocompatibility, and enhance efficacy. − Notably, imidazoles, such as clotrimazole, miconazole, ketoconazole, etc., are early antifungal drugs that are still widely used in clinics. The narrow antifungal spectrum for imidazole drugs highlights the necessity to develop new structural broad-spectrum antifungal agents.
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