“…Indeed, pyridine and furan derivatives have been recently reported to possess pharmacological potential as fungicidal, 6,7 anti-inflammatory, 8,9 antiviral, 10,11 antibacterial, 12,13 and even anticancer agents. 14,15 On the other hand, heterocyclic compound bearing β-ketoenol functionality has been a fruitful source of inspiration for pharmaceutical and medicinal industries due to their widespread potential biological activities and their versatile utility in the world of medicinal chemistry, 16,17 such as antioxidant, 18 anti-inflammatory, 19 anticancer, 20 and antifungal 21 activities. In this context, β-keto-enol functionality was found in numerous natural products such as the curcumin and its derivatives (Figure 1), which have spurred numerous studies in medicinal chemistry.…”