Discovery of a Plant 14‐3‐3 Inhibitor Possessing Isoform Selectivity and In Planta Activity
Kotaro Nishiyama,
Yusuke Aihara,
Takehiro Suzuki
et al.
Abstract:Synthetic modulators for plant 14‐3‐3s are promising chemical tools both for understanding the 14‐3‐3‐related signaling pathways and controlling plant physiology. Here, we describe a novel small‐molecule inhibitor for 14‐3‐3 proteins ofArabidopsis thaliana. The inhibitor was identified from unexpected products in DMSO stock solution of an in‐house chemical library. Mass spectroscopy, mutant‐based analyses, fluorescence polarization assays, and thermal shift assaysrevealed that the inhibitor covalently binds to… Show more
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