Biochemical Pharmacology volume 82, issue 7, P755-768 2011 DOI: 10.1016/j.bcp.2011.06.036 View full text
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Shigeo Hayashi, Yoko Sumi, Naomi Ueno, Akio Murase, Junji Takada

Abstract: Cyclooxygenase (COX) has been considered as a significant pharmacological target because of its pivotal roles in the prostaglandin biosynthesis and following cascades that lead to various (patho)physiological effects. Non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of fever, inflammation, and pain; however, nonselective COX inhibitors exhibit serious side-effects such as gastrointestinal damage because of their inhibitory activities agains…

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