2011
DOI: 10.1016/j.bmcl.2010.10.131
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Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

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Cited by 97 publications
(69 citation statements)
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“…The notion that nonstructural proteins may be involved in virus assembly has been demonstrated in related viruses (21,24,37,39) and, therefore, warrants further investigation in the case of HCV. Inhibition of virus assembly is currently being considered an alternative therapeutic strategy for other viruses such as HIV (7,9,18,45). Therefore, a finite protein-protein interaction that is essential to infectious virion production, such as the one described here, may represent an attractive target for the development of future HCV therapies.…”
Section: Discussionmentioning
confidence: 99%
“…The notion that nonstructural proteins may be involved in virus assembly has been demonstrated in related viruses (21,24,37,39) and, therefore, warrants further investigation in the case of HCV. Inhibition of virus assembly is currently being considered an alternative therapeutic strategy for other viruses such as HIV (7,9,18,45). Therefore, a finite protein-protein interaction that is essential to infectious virion production, such as the one described here, may represent an attractive target for the development of future HCV therapies.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, the benzodiazepine (BD) and the benzimidazole (BM) series were reported to inhibit virion release or prevent virus maturation, respectively (61,62). In the case of the BD series, molecular studies, complemented by nuclear magnetic resonance and crystallography approaches, have shown that compounds from this class inhibited HIV particle release by blocking assembly of immature capsids (63).…”
Section: Discussionmentioning
confidence: 99%
“…145 Optimization of the benzodiazepine series led to a compound with significantly improved potency. 146 Together, these studies indicate that HIV-1 CA is a potential drug target.…”
mentioning
confidence: 99%