“…Many, such as CP-101,606 (Traxoprodil; Chenard et al, 1995 ), Ro25-6981 ( Fischer et al, 1997 ), or besonprodil ( Chizh et al, 2001 ), share the same phenylethanolamine scaffold as ifenprodil. Others, including a number of highly potent and orally active GluN2B antagonists such as EVT-101 ( Kemp and Tasker, 2009 ) and to a lesser extent MK-22 ( Layton et al, 2011 ), bear strikingly different structural motifs, thus questioning whether these compounds adopt a similar binding mode to ifenprodil. Crystal structures recently established the existence of a "phenylethanolamine binding site" at a dimer interface between GluN1 and GluN2B NTDs ( Karakas et al, 2011 ; Karakas and Furukawa, 2014 ; Lee et al, 2014 ).…”