Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists
Camilla Russo,
Pasquale Russomanno,
Vincenzo Maria D’Amore
et al.
Abstract:NOD1 and NOD2 are members of the pattern recognition receptors involved in the innate immune response. Overactivation of NOD1 is implicated in inflammatory disorders, multiple sclerosis, and cancer cell metastases. NOD1 antagonists would represent valuable pharmacological tools to gain further insight into protein roles, potentially leading to new therapeutic strategies. We herein report the expansion of the chemical space of NOD1 antagonists via a multicomponent synthetic approach affording a novel chemotype,… Show more
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