Discovery and validation of the prognostic value of the lncRNAs encoding snoRNAs in patients with clear cell renal cell carcinoma

Yang, Wuping; Zhang, Kenan; Li, Lei; Ma, Kaifang; Hong, Bo; Gong, Yanqing; Gong, Kan

doi:10.18632/aging.102894

Cited by 34 publications

(34 citation statements)

References 53 publications

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“…With the study of the molecular mechanism of lncRNAs in tumors, lncRNAs may become new tumor biomarkers for the diagnosis and treatment of cancer targets [ 83 ]. Yang et al [ 84 ] used RNA-seq and survival data in the TCGA database to analyze the expression profiles of 20 SNHGs and discussed their prognostic value in clear cell renal cell carcinoma (ccRCC). Results of the study indicated that SNHG3 and SNHG15 act as diagnostic markers and indicators and may have great clinical value to evaluate the survival and progression of ccRCC.…”

Section: Perspectives In Clinical Practicementioning

confidence: 99%

LncRNA SNHG3, a potential oncogene in human cancers

Mei

et al. 2020

Cancer Cell Int

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Long noncoding RNAs (lncRNAs) are composed of > 200 nucleotides; they lack the ability to encode proteins but play important roles in a variety of human tumors. A large number of studies have shown that dysregulated expression of lncRNAs is related to tumor oncogenesis and progression. Emerging evidence shows that SNHG3 is a novel oncogenic lncRNA that is abnormally expressed in various tumors, including osteosarcoma, liver cancer, lung cancer, etc. SNHG3 primarily competes as a competitive endogenous RNA (ceRNA) that targets tumor suppressor microRNAs (miRNAs) and ceRNA mechanisms that regulate biological processes of tumors. In addition, abnormal expression of SNHG3 is significantly correlated with patient clinical features. Upregulation of SNHG3 contributes to biological functions, including tumor cell proliferation, migration, invasion and EMT. Therefore, SNHG3 may represent a potential diagnostic and prognostic biomarker, as well as a novel therapeutic target.

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Section: Perspectives In Clinical Practicementioning

confidence: 99%

LncRNA SNHG3, a potential oncogene in human cancers

Mei

et al. 2020

Cancer Cell Int

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“…20 Some researchers have reported the upregulated expression of SNHG22 in EOC, PTC, and ccRCC, and whose expression indicated poor prognosis in the three types of human malignancies. [11][12][13] In this study, we rst explored the expression patterns of SNHG22 in ANT, CRA, and CRC tissues, and found that SNHG22 expression was gradually upregulated in ANTs, CRA, and TTs. The high expression level of SNHG22 was associated with advanced T stage, node involvement, metastasis, and poor survival in CRC patients.…”

Section: Discussionmentioning

confidence: 99%

“…11 SNHG22 was then determined to be highly expressed in PTC and ccRCC. 12,13 We also checked the effects of SNHG22 on cell phenotype of CRC. We did prove that SNHG22 could promote cell proliferation, invasion, migration, and inhibit cell apoptosis of CRC in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…10 Several reports have found that SNHG22 contributed to cell growth, migration, invasion, and chemotherapy resistance in epithelial ovarian carcinoma (EOC), papillary thyroid cancer (PTC) and clear cell renal cell carcinoma (ccRCC). [11][12][13] Besides, upregulated SNHG22 was shown in TTs as compared with that in the ANTs, and whose high expression indicated poor prognosis in the three types of human malignancies. [11][12][13] To our knowledge, the biological role and expression patterns of SNHG22 have not been examined in human CRC.…”

Section: Introductionmentioning

confidence: 98%

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LncRNA SNHG22 Sponges miR-128-3p to Promote Progression of Colorectal Cancer through Upregulating E2F3

Jianning¹,

Wang²,

Xuyang³

et al. 2020

Preprint

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Background: Long non-coding RNA (lncRNA) termed small nucleolar RNA host gene 22 (SNHG22) has been reported as a crucial regulator in several types of human cancers. In this study, we aimed to evaluate the function and mechanism of SNHG22 in colorectal cancer (CRC) progression. Methods: Quantitative RT-PCR (qRT-PCR) was used to detect the expression of SNHG22 in adenoma, tumor tissues (TTs), and adjacent nontumorous tissues (ANTs). The biological behaviors of SNHG22 in CRC cell lines were explored both in vitro (CCK-8 assay, flow cytometry, wound scratch, and transwell assays) and in vivo (nude mouse xenograft model). The interaction between SNHG22 and miR-128-3p, and the target genes of miR-128-3p were explored by online tools, qRT-PCR, western blot, and dual-luciferase reporter assay. Results: SNHG22 expression was gradually upregulated in ANTs, adenoma, and TTs. High expression levels of SNHG22 were significantly related to advanced clinicopathological factors and worse survival in patients with CRC. SNHG22 knockdown markedly prohibited CRC cell proliferation, migration, and invasion; and drove cell apoptosis in vitro; and hindered tumor growth in vivo. Mechanistic investigation showed that SNHG22 could bind to microRNA-128-3p (miR-128-3p) and attenuate its inhibitory effects on the expression levels and activity of E2F3. Rescue experiments exhibited that miR-128-3p inhibition or E2F3 upregulation can offset the functions of SNHG22 knockdown in CRC cells. Conclusion: Our findings support the existence of an interactive regulatory network of SNHG22, miR-128-3p, and E2F3 in CRC cell lines, indicating that the SNHG22/miR-128-3p/E2F3 axis is a novel diagnostic and therapeutic target in CRC.

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“…Small nucleolar RNA host gene 17 (SNHG17) was reported to accelerate cell proliferation and invasion in castrationresistant prostate cancer (CRPC) by targeting the miR-144/CD51 axis [20]. Furthermore, as lncRNAs that encode small nucleolar RNAs (snoRNAs), the prognostic value of SNHG17 and SNHG15 in KIRC patients has been investigated, and DNA hypomethylation might play a key role in elevated SNHG15 transcription in KIRC [21]. Recently, AC026356.2 and MELTF-AS1 were identi ed as immune-related lncRNA and showed a signi cant relationship with KIRC prognosis [22].…”

Section: Discussionmentioning

confidence: 99%

Identification of Autophagy-Related Long Non-Coding RNA Prognostic Signature for Clear Cell Renal Cell Carcinoma

Cui

Zhang

Miao

et al. 2020

Preprint

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Background: Studies over the past decade have shown that long non-coding RNAs (lncRNAs) play an essential role in the tumorigenesis and progression of kidney renal clear cell carcinoma (KIRC). Meanwhile, autophagy has been demonstrated to regulate KIRC pathogenesis and targeting therapy resistance. However, the prognostic value of autophagy-related lncRNAs in KIRC patients has not been reported before.Methods: In this study, we obtained transcriptome data of 611 KIRC cases from the TCGA database and 258 autophagy-related mRNAs from the HADb database to identify autophagy-related lncRNAs by co-expression network. A prognostic model was then established basing on these autophagy-related lncRNAs, dividing patients into high-risk and low-risk groups. Survival analysis, clinical variables dependent receiver operating characteristic (ROC) analyses, univariate/multivariate Cox analyses, and clinical correlation analysis were performed based on risk signature with R language. Gene set enrichment analysis (GSEA) was then performed to investigate the potential mechanism of the risk signature promoting KIRC progression with GSEA software. Results: A total of 17 lncRNAs were screened out and all these lncRNAs were found significantly related to KIRC patients' overall survival in subsequent survival analyses. Besides, the overall survival time in the high-risk group was much poorer than in the low-risk group. The ROC analysis revealed that the prognostic value of risk signature was better than age, gender, grade, and N stage. Univariate/multivariate analyses suggested that the risk signature was an independent predictive factor for KIRC patients. Immune-related pathways were dramatically enriched in high-risk patients according to GSEA. Conclusions: In summary, our identified 17 autophagy-related lncRNAs had prognostic value for KIRC patients which may function in Immunomodulation.

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Discovery and validation of the prognostic value of the lncRNAs encoding snoRNAs in patients with clear cell renal cell carcinoma

Cited by 34 publications

References 53 publications

LncRNA SNHG3, a potential oncogene in human cancers

LncRNA SNHG3, a potential oncogene in human cancers

LncRNA SNHG22 Sponges miR-128-3p to Promote Progression of Colorectal Cancer through Upregulating E2F3

Identification of Autophagy-Related Long Non-Coding RNA Prognostic Signature for Clear Cell Renal Cell Carcinoma

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