Discovery and Validation of Biomarkers to Guide Clinical Management of Pneumonia in African Children

Huang, Honglei; Ideh, Readon C.; Gitau, Evelyn; Thézénas, Marie‐Laëtitia; Jallow, Muminatou; Ebruke, Bernard E.; Chimah, Osaretin; Oluwalana, Claire; Karanja, Henri; Mackenzie, Grant; Adegbola, Richard A.; Kwiatkowski, Dominic P.; Kessler, Benedikt M.; Berkley, James A.; Howie, Stephen R. C.; Casals-Pascual, Climent

doi:10.1093/cid/ciu202

Cited by 49 publications

(63 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the prediction by the World Health Organization there are 151.8 million new cases of pneumonia each year in children, more than 95 % of them in developing countries and 13.1 million or 8.7 % of which are severe enough to require hospitalization (2,3). About 2 million pneumonia deaths occur each year in children mainly in undeveloped countries (4). Although the problem is severe and causes many complications, there is still a little evidence-based data on CAP (5).…”

Section: Introductionmentioning

confidence: 99%

Value of neutrophil to lymphocyte and platelet to lymphocyte ratios in pneumonia

Kartal¹,

Kartal²

2017

BLL

View full text Add to dashboard Cite

PURPOSE: In our study, we aimed to evaluate neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with Community-acquired pneumonia (CAP). METHODS: This is a retrospective study consisting of 114 patients with CAP and 50 control subjects. Patients with CAP were divided into 2 groups, as inpatient and outpatient. RESULTS: The main fi ndings of our study were that NLR, PLR and CRP levels were signifi cantly higher in CAP than those in the control group. These biomarkers were also higher in inpatient group than outpatient group, but not statistically signifi cant. CONCLUSION: To our knowledge, this is the fi rst study which investigated the role of NLR and PLR as infl ammatory biomarkers and the difference in inpatients and outpatients with CAP and their correlation with CRP values in children. However, larger prospective studies are needed to establish their utility as a predictor for the presence of CAP (Tab. 1, Fig. 2, Ref. 9). Text in PDF www.elis.sk. KEY WORDS: CRP, infl ammatory biomarkers, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, pneumonia.

show abstract

Section: Introductionmentioning

confidence: 99%

Value of neutrophil to lymphocyte and platelet to lymphocyte ratios in pneumonia

Kartal¹,

Kartal²

2017

BLL

View full text Add to dashboard Cite

show abstract

“…Recently, a study was conducted with African children who had pneumonia. This study revealed that serum NGAL level had high specificity and sensitivity to distinguish severe pneumonia from mild pneumonia and bacterial pneumonia from non-bacterial pneumonia [19]. COPD-AE is mainly the result of bacterial infections.…”

Section: Discussionmentioning

confidence: 78%

Neutrophil Gelatinase-Associated Lipocalin: A New Biomarker for COPD Acute Exacerbation

Gümüş¹,

Çınarka²,

Haziroglu³

et al. 2014

JLPRR

View full text Add to dashboard Cite

“…Increased haptoglobin is associated with bacterial pneumonia (39,(44)(45)(46)(47), probably because of the role of neutrophils in clearance of bacterial infections in the lungs. The persistence of haptoglobin increases in bacterial pneumonia may also explain the usefulness of this marker for identifying bacterial infections (46).…”

Section: Discussionmentioning

confidence: 99%

“…Although association of several markers with the three etiologies has been shown, no individual marker has diagnostic value (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). Haptoglobin and lipocalin-2 were found to accurately distinguish probable bacterial pneumonia from malaria (39).…”

mentioning

confidence: 99%

Responses to Bacteria, Virus, and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia

Valim

Ahmad

Lanaspa

et al. 2016

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: Plasma-detectable biomarkers that rapidly and accurately diagnose bacterial infections in children with suspected pneumonia could reduce the morbidity of respiratory disease and decrease the unnecessary use of antibiotic therapy.Objectives: Using 56 markers measured in a multiplexed immunoassay, we sought to identify proteins and protein combinations that could discriminate bacterial from viral or malarial diagnoses. Methods:We selected 80 patients with clinically diagnosed pneumonia (as defined by the World Health Organization) who also met criteria for bacterial, viral, or malarial infection based on clinical, radiographic, and laboratory results. Ten healthy community control subjects were enrolled to assess marker reliability. Patients were subdivided into two sets: one for identifying potential markers and another for validating them.Measurements and Main Results: Three proteins (haptoglobin, tumor necrosis factor receptor 2 or IL-10, and tissue inhibitor of metalloproteinases 1) were identified that, when combined through a classification tree signature, accurately classified patients into bacterial, malarial, and viral etiologies and misclassified only one patient with bacterial pneumonia from the validation set. The overall sensitivity and specificity of this signature for the bacterial diagnosis were 96 and 86%, respectively. Alternative combinations of markers with comparable accuracy were selected by support vector machine and regression models and included haptoglobin, IL-10, and creatine kinase-MB.Conclusions: Combinations of plasma proteins accurately identified children with a respiratory syndrome who were likely to have bacterial infections and who would benefit from antibiotic therapy. When used in conjunction with malaria diagnostic tests, they may improve diagnostic specificity and simplify treatment decisions for clinicians.

show abstract

Discovery and Validation of Biomarkers to Guide Clinical Management of Pneumonia in African Children

Abstract: Lipocalin 2 distinguishes severe and bacterial pneumonia from nonsevere and nonbacterial pneumonia with a high level of precision. The clinical impact of this biomarker requires large-scale clinical evaluation.

Cited by 49 publications

References 35 publications

Value of neutrophil to lymphocyte and platelet to lymphocyte ratios in pneumonia

Value of neutrophil to lymphocyte and platelet to lymphocyte ratios in pneumonia

Neutrophil Gelatinase-Associated Lipocalin: A New Biomarker for COPD Acute Exacerbation

Responses to Bacteria, Virus, and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia

Contact Info

Product

Resources

About