Discovery and preliminary validation of a new panel of personalized ovarian cancer biomarkers for individualized detection of recurrence
Annie Ren,
Ioannis Prassas,
Antoninus Soosaipillai
et al.
Abstract:Background: Following first-line treatment, over 80% of advanced ovarian cancer cases suffer recurrence. Treatment of patients with recurrence based on CA125 has not resulted in improvements in outcome postulating that we need biomarkers for earlier detection. A tumor-specific array of serum proteins with advanced proteomic methods could identify personalized marker signatures that detect relapse at a point where early intervention may improve outcome. Methods: For our discovery phase, we employed the proximit… Show more
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