Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease
Yuan Li,
Tingting Xu,
Yue Zhao
et al.
Abstract:Inflammatory bowel disease (IBD) is a multifactorial
chronic inflammation
of the intestine and has become a global public health concern. A
farnesoid X receptor (FXR) was recently reported to play a key role
in hepatic-intestinal circulation, intestinal metabolism, immunity,
and microbial regulation, and thus, it becomes a promising therapeutic
target for IBD. In this study, we identified a series of nonbile acid
FXR agonists, in which 33 novel compounds were designed and synthesized
by the structure-based dru… Show more
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