Discovery and mode of action of cyclopyrimorate: A new paddy rice herbicide

Shino, Mamiko; Hamada, Takahiro; Shigematsu, Yoshio; Hirase, Kangetsu; Banba, Shinichi; Tsukamoto, Yoshihisa; Kadotani, Junji

doi:10.1016/b978-0-12-821035-2.00033-4

Cited by 6 publications

(8 citation statements)

References 12 publications

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“…Homogentisate-solanesyltransferase, a recently discovered herbicidal MT, catalyzes the decarboxylation and prenylation of homogentisate to form 2-methyl-6-solanesyl-1,4-benzoquinol during the biosynthesis of plastoquinone, which in turn is involved in the biosynthesis of carotenoids as a cofactor of phytoene desaturase. Mitsui Chemicals Agro, Inc. (Tokyo, Japan) recently released a selective herbicide cyclopyrimorate ( 45 ) against rice crop weeds acting on this MT [ 62 ].…”

Section: Current Trends In Herbicide Developmentmentioning

confidence: 99%

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Berestetskiy

2023

Plants

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Weeds are a permanent component of anthropogenic ecosystems. They require strict control to avoid the accumulation of their long-lasting seeds in the soil. With high crop infestation, many elements of crop production technologies (fertilization, productive varieties, growth stimulators, etc.) turn out to be practically meaningless due to high yield losses. Intensive use of chemical herbicides (CHs) has led to undesirable consequences: contamination of soil and wastewater, accumulation of their residues in the crop, and the emergence of CH-resistant populations of weeds. In this regard, the development of environmentally friendly CHs with new mechanisms of action is relevant. The natural phytotoxins of plant or microbial origin may be explored directly in herbicidal formulations (biorational CHs) or indirectly as scaffolds for nature-derived CHs. This review considers (1) the main current trends in the development of CHs that may be important for the enhancement of biorational herbicides; (2) the advances in the development and practical application of natural compounds for weed control; (3) the use of phytotoxins as prototypes of synthetic herbicides. Some modern approaches, such as computational methods of virtual screening and design of herbicidal molecules, development of modern formulations, and determination of molecular targets, are stressed as crucial to make the exploration of natural compounds more effective.

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Section: Current Trends In Herbicide Developmentmentioning

confidence: 99%

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Berestetskiy

2023

Plants

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“…Furthermore, no new mode of action herbicide has been released in the market for more than 30 years ( Duke, 2012 ), which adds further pressure in controlling the increased number of herbicide-resistant weeds globally. Although herbicides with new modes of action, such as cinmethylin ( Campe et al, 2018 ), tetflupyrolimet ( Dayan, 2019 ; Dayan et al, 2019 ), and cyclopyrimorate ( Shino et al, 2021 ) have been developed, weed control cannot be heavily dependent on utilizing novel herbicides as weeds can also develop resistance. From 1957 to 2020, the global reported number of unique cases of herbicide-resistant weeds has increased from 2 to 507 ( Heap, 2022 ).…”

Section: Challenges In Weed Managementmentioning

confidence: 99%

Biotechnological Road Map for Innovative Weed Management

et al. 2022

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In most agriculture farmlands, weed management is predominantly reliant on integrated weed management (IWM) strategies, such as herbicide application. However, the overuse and misuse of herbicides, coupled with the lack of novel active ingredients, has resulted in the uptrend of herbicide-resistant weeds globally. Moreover, weedy traits that contribute to weed seed bank persistence further exacerbate the challenges in weed management. Despite ongoing efforts in identifying and improving current weed management processes, the pressing need for novel control techniques in agricultural weed management should not be overlooked. The advent of CRISPR/Cas9 gene-editing systems, coupled with the recent advances in “omics” and cheaper sequencing technologies, has brought into focus the potential of managing weeds in farmlands through direct genetic control approaches, but could be achieved stably or transiently. These approaches encompass a range of technologies that could potentially manipulate expression of key genes in weeds to reduce its fitness and competitiveness, or, by altering the crop to improve its competitiveness or herbicide tolerance. The push for reducing or circumventing the use of chemicals in farmlands has provided an added incentive to develop practical and feasible molecular approaches for weed management, although there are significant technical, practical, and regulatory challenges for utilizing these prospective molecular technologies in weed management.

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“…Homogentisate-solanesyltransferase, a recently discovered herbicidal MT, catalyzes the decarboxylation and prenylation of homogentisate to form 2-methyl-6solanesyl-1,4-benzoquinol during the biosynthesis of plastoquinone, which in turn is involved in the biosynthesis of carotenoids as a cofactor of phytoene desaturase. Mitsui Chemicals Agro, Inc. (Japan) recently released a selective herbicide cyclopyrimorate (45) against rice crop weeds acting on this MT [62].…”

Section: Mechanisms Of Action and Molecular Targets Of Herbicidesmentioning

confidence: 99%

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Berestetskiy¹

2022

Preprint

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Weeds are a permanent component of anthropogenic ecosystems, which requires strict control to avoid the accumulation of their long–lasting seeds in the soil. With high crop infestation, many elements of crop production technologies (fertilization, productive varieties, growth stimulators, etc.) turn out to be practically meaningless due to high yield losses. Intensive use of chemical herbicides (CH) has led to undesirable consequences: contamination of soil and wastewater, accumulation of their residues in the crop, the emergence of CH-resistant populations of weeds. In this regard, the development of environmentally friendly CH with new mechanisms of action is relevant. Natural phytotoxins of plant or microbial origin may be directly explored in herbicidal formulations (biorational CH) or indirectly as scaffolds for nature-derived CH. This review considers: 1) the main current trends in the development of CH that may be important for enhancement of biorational herbicides; 2) advances in the development and practical application of natural compounds for weed control; 3) the use of phytotoxins as prototypes of synthetic herbicides. Some modern approaches such as computational methods of virtual screening and design herbicidal molecules, development of modern formulations, determination of molecular targets are stressed as important to make exploration of natural compounds more effective.

show abstract

Discovery and mode of action of cyclopyrimorate: A new paddy rice herbicide

Cited by 6 publications

References 12 publications

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Biotechnological Road Map for Innovative Weed Management

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

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