Discovery and identification of potential biomarkers for alcohol‐induced oxidative stress based on cellular metabolomics

Hu, Qingping; Wei, Jianteng; Fei, Xiulan; Hao, Yuwei; Pei, Dong; Di, Duolong

doi:10.1002/bmc.3907

Cited by 10 publications

(8 citation statements)

References 55 publications

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“…However, this study assessed the influence of longer-term exposure to smoking and alcohol, but did not specifically test the effect of these exposures in the short period prior to blood collection. Alcohol-related metabolome alterations have been previously associated with oxidative stress [30,31] and diseases, including cancers [32,33]. However, we do not report any significant differences in studied metabolites by alcohol or tobacco consumption around blood sample collection.…”

Section: Discussioncontrasting

confidence: 74%

Impact of Pre-Blood Collection Factors on Plasma Metabolomic Profiles

et al. 2020

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Demographic, lifestyle and biospecimen-related factors at the time of blood collection can influence metabolite levels in epidemiological studies. Identifying the major influences on metabolite concentrations is critical to designing appropriate sample collection protocols and considering covariate adjustment in metabolomics analyses. We examined the association of age, sex, and other short-term pre-blood collection factors (time of day, season, fasting duration, physical activity, NSAID use, smoking and alcohol consumption in the days prior to collection) with 133 targeted plasma metabolites (acylcarnitines, amino acids, biogenic amines, sphingolipids, glycerophospholipids, and hexoses) among 108 individuals that reported exposures within 48 h before collection. The differences in mean metabolite concentrations were assessed between groups based on pre-collection factors using two-sided t-tests and ANOVA with FDR correction. Percent differences in metabolite concentrations were negligible across season, time of day of collection, fasting status or lifestyle behaviors at the time of collection, including physical activity or the use of tobacco, alcohol or NSAIDs. The metabolites differed in concentration between the age and sex categories for 21.8% and 14.3% metabolites, respectively. In conclusion, extrinsic factors in the short period prior to collection were not meaningfully associated with concentrations of selected endogenous metabolites in a cross-sectional sample, though metabolite concentrations differed by age and sex. Larger studies with more coverage of the human metabolome are warranted.

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Section: Discussioncontrasting

confidence: 74%

Impact of Pre-Blood Collection Factors on Plasma Metabolomic Profiles

et al. 2020

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“…Hu et al. discovered eight marker candidates viz., malic acid, oxidized glutathione, γ-glutamyl-cysteinyl-glycine, ATP, phenylalanine, AMP, nitrotyrosine and tryptophan by metabolomic approach [ 82 ]. Zeng et al.…”

Section: Cytokines and Proteomic Markersmentioning

confidence: 99%

Liver Fibrosis: A Compilation on the Biomarkers Status and Their Significance During Disease Progression

et al. 2017

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Liver fibrosis occurs in response to different etiologies of chronic liver injury. Diagnosing degree of liver fibrosis is a crucial step in evaluation of severity of the disease. An invasive liver biopsy is the gold standard method associated with pain and complications. Biomarkers to detect liver fibrosis include direct markers of extracellular matrix turnover and indirect markers as a reflection of liver dysfunction. Although a single marker may not be useful for successful management, a mathematical equation combining tests might be effective. The main purpose of this review is to understand the diagnostic accuracy of biomarkers and scoring systems for liver fibrosis. Advances in -omics approach have generated clinically significant biomarker candidates for liver fibrosis that need further evaluation.

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“…Activation of spinal cord microglia, mGlu5 spinal cord receptors, and hypothalamicpituitary-adrenal axis appear to be implicated in this process [92][93][94][95][96][97]. Oxidative stress also leads to the indirect damage of nerve fibers via the release of free radicals and proinflammatory cytokines with protein kinase C and ERK kinase phosphorylation [98][99][100][101]. Besides, ALN is characterized by insulin and insulin-like growth factor (IGF) resistance, which results in impaired trophic factor signaling [102,103].…”

Section: Aln Pathophysiologymentioning

confidence: 99%

Alcohol-Induced Neuropathy in Chronic Alcoholism: Causes, Pathophysiology, Diagnosis, and Treatment Options

et al. 2020

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Purpose of the Review Alcohol abuse causes a wide range of disorders that affect the nervous system. These include confusion, cerebellar ataxia, peripheral neuropathy, and cognitive impairment. Chronic and excessive alcohol consumption is the primary cause of peripheral neuropathy. It is worth noting that peripheral neuropathy has no reliable treatment due to the poor understanding of its pathology. Recent Findings Coasting is a major feature of alcoholic neuropathy, largely due to chronic alcohol abuse. Its major features are hyperalgesia, allodynia, and burning pain. Even though much research was done in this area, still we do not have a full understanding of the mechanism of alcoholic neuropathy. However, some theories have been proposed. These include direct or indirect effects of alcohol metabolites, impaired axonal transport, suppressed excitatory nerve pathway activity, or imbalance in neurotransmitters. Activation of spinal cord microglia, mGlu5 spinal cord receptors, and hypothalamic-pituitary-adrenal axis also seem to be implicated in the pathophysiology of this alcoholic neuropathy. The goal of treatment is to impede further damage to the peripheral nerves while also restoring their normal physiology. Alcohol abstinence, intake of balanced diets, and treatment with medications are suggested including benfotiamine, alpha-lipoic acid, acetyl-l-carnitine, vitamin E, methylcobalamin, myo-inositol, N-acetylcysteine, capsaicin, tricyclic antidepressants, or antiepileptic drugs. Summary This review focuses on the many pathways that play a role in the onset and development of alcohol-induced neuropathy, as well as present the possible treatment strategies of this disorder, providing insights into a further search of new treatment modalities.

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Discovery and identification of potential biomarkers for alcohol‐induced oxidative stress based on cellular metabolomics

Cited by 10 publications

References 55 publications

Impact of Pre-Blood Collection Factors on Plasma Metabolomic Profiles

Impact of Pre-Blood Collection Factors on Plasma Metabolomic Profiles

Liver Fibrosis: A Compilation on the Biomarkers Status and Their Significance During Disease Progression

Alcohol-Induced Neuropathy in Chronic Alcoholism: Causes, Pathophysiology, Diagnosis, and Treatment Options

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