Discovery and in vitro Evaluation of Novel Serotonin 5‐HT2A Receptor Ligands Identified Through Virtual Screening
Agata Zięba,
Damian Bartuzi,
Piotr Stępnicki
et al.
Abstract:The 5‐HT2A receptor is a molecular target of high pharmacological importance. Ligands of this protein, particularly atypical antipsychotics, are useful in the treatment of numerous mental disorders, including schizophrenia and major depressive disorder. Structure‐based virtual screening using a 5‐HT2A receptor complex was performed to identify novel ligands for the 5‐HT2A receptor, serving as potential antidepressants. From the Enamine screening library, containing over 4 million compounds, 48 molecules were s… Show more
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