Discovery and development of a synthetic peptide derived from lactoferrin for clinical use

Tryptophan-containing milk protein-derived dipeptides inhibit xanthine oxidase

“…LF has been described as a multifunctional milk protein displaying a range of bioactivities. Intact and hydrolyzed lactoferrin have mainly been reported as antimicrobial [7,9,12,28,35,52], anti-inflammatory [14,28,36] opioid antagonist [12] and antioxidant agents [71]. Intact LF did not inhibit XO (Table 3).…”

Application of Antimicrobial Peptides for Disease Control in Plants

“…While most AMPs belong to one of the four classes, some AMPs do not belong to any of these groups. Some of which contain two different structural components (Brouwer et al 2011). Also, many peptides form their active structure only when they interact with the membranes of target cells.…”

“…They are a first line of defense in plants and animals, and resistance against them is much less observed compared with current antibiotics (Hancock 1997). AMPs from various sources have been demonstrated to confer resistance against fungal and bacterial pathogens in an array of genetically engineered plant species, including Arabidopsis (Maloy 1995), tobacco (Ramamoorthy et al 2006;Kang et al 2009;, Chinese cabbage (Jung et al 2012), rice (Gordon et al 2005;Oyston et al 2009), tomato (Lupetti et al 2000), cotton (Lupetti et al 2003), potato (Brouwer et al 2011), pear (Hwang et al 1998), banana (Ramamoorthy et al 2006) and hybrid poplar (Nguyen et al 2005).…”

Milk Derived Peptides with Immune Stimulating Antiviral Properties

“…Similarly, two peptide inhibitors of interleukin-10 may be applied to increase anti-hepatitis C virus immune response by restoring the immune stimulatory capabilities of dendritic cells, which have been suppressed by high levels of interleukin-10 [194]. Moreover, candidacidal activities of a synthetic peptide from human lactoferrin fraction 1-11 and 21-31 have been investigated for killing of multidrug-resistant pathogens [195][196][197][198][199]. Present research results, such as phase I safety and tolerability trials of human lactoferrin by AM Pharma [22], indicate that human lactoferrin 1-11 acts by selectively stimulating the innate immune system [200].…”

“…Present research results, such as phase I safety and tolerability trials of human lactoferrin by AM Pharma [22], indicate that human lactoferrin 1-11 acts by selectively stimulating the innate immune system [200]. Thus, human lactoferrin 1-11 is more likely to be an interesting candidate for further exploration in various clinical tests, such as coating for dental or bone implants, in biosensing applications or in radiopharmaceutical therapy [199].…”