2015
DOI: 10.1002/cbic.201500147
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Discovery and Characterization of New Hydroxamate Siderophores, Baumannoferrin A and B, produced by Acinetobacter baumannii

Abstract: Acinetobacter baumannii AYE does not produce acinetobactin but grows under iron limitation. Accordingly, analyses of AYE iron-restricted culture supernatants resulted in the isolation of two fractions, which contained only hydroxamates and showed siderophore activity. Structural analyses identified baumannoferrin A and baumannoferrin B, which differ only by a double bond. These siderophores are composed of citrate, 1,3-diaminopropane, 2,4-diaminobutyrate, decenoic acid, and α-ketoglutarate. Analysis of the AYE… Show more

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Cited by 60 publications
(87 citation statements)
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“…Siderophore production by a clinical isolate of Acinetobacter calcoaceticus was also reported in the literature . Recently, Actis and co‐workers have identified two new hydroxamate siderophores baumannoferrin A and B from the culture supernatants of Acinetobacter baumannii AYE . To the best of our knowledge, no information is available on the siderophore production by the bacterium A. soli .…”
Section: Introductionmentioning
confidence: 83%
“…Siderophore production by a clinical isolate of Acinetobacter calcoaceticus was also reported in the literature . Recently, Actis and co‐workers have identified two new hydroxamate siderophores baumannoferrin A and B from the culture supernatants of Acinetobacter baumannii AYE . To the best of our knowledge, no information is available on the siderophore production by the bacterium A. soli .…”
Section: Introductionmentioning
confidence: 83%
“…baumannii ATCC 17978 encodes siderophore biosynthetic systems for acinetobactin (73), baumanoferrin (39), and fimsbactin (40), as well as Fur-regulated (34,35) TBDT for ferric siderophores that it does not synthesize (e.g., FhuA-Fc, FhuE-Ferhodotorulate, and FepA-FeEnt). Hence, A. baumannii ORF A1S_0980-A1S_0980 encodes AbaFepA, the iron-regulated OM receptor for FeEnt, which efficiently transported the catecholate ferric siderophore.…”
Section: Discussionmentioning
confidence: 99%
“…Acinetobactin is a high-affinity, catecholate siderophore and a virulence factor (36)(37)(38) that is nearly ubiquitous among the currently sequenced A. baumannii strains. At least two other siderophore biosynthetic gene clusters exist in A. baumannii (34), one for the hydroxamates baumanoferrin A and B (39) and another for fimsbactin (40). Besides the secretion of these siderophores and uptake of their ferric complexes, A. baumannii produces transporters for iron complexes of other siderophores that it does not produce.…”
mentioning
confidence: 99%
“…Surface-associated motility of the nosocomial ␥-proteobacterial pathogen Acinetobacter baumannii was found to depend on biosynthesis of 1,3diaminopropane, a relatively rare polyamine (92). It is perhaps salient that A. baumannii also uses 1,3-diaminopropane and its biosynthetic precursor 2,4-diaminobutyrate in the synthesis of the iron-scavenging siderophores baumannoferrin A and B (93). Polyamine-dependent surface behaviors among different species are listed in Fig.…”
Section: Roles In Biofilm Development and Other Surface Behaviorsmentioning
confidence: 99%