Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity
Francis Hubler,
Dorte Renneberg,
Hervé Siendt
et al.
Abstract:C5a is an anaphylatoxin protein produced by the cleavage of the complement system's component C5 protein. It signals through the G-proteincoupled receptor C5a receptor 1 (C5aR1) to induce the chemotaxis of primarily neutrophils and monocytes and the release of inflammatory molecules. A large body of evidence linking C5aR1 signaling to acute and chronic inflammatory disorders has triggered interest in developing potent C5aR antagonists. Herein we report the discovery of new C5aR1 antagonistic chemical classes. … Show more
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