Discovery and anticancer evaluation of a formononetin derivative against gastric cancer SGC7901 cells

Yao, Jianning; Zhang, Xuexiu; Zhang, Yanzhen; Li, Jia-heng; Zhao, Dan; Gao, Bing; Zhou, Haining; Gao, Shilin; Zhang, Lianfeng

doi:10.1007/s10637-019-00767-7

Cited by 25 publications

(12 citation statements)

References 35 publications

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“…Formononetin derivative is designed and synthesized via a molecular hybridization strategy based on formononetin. Formononetin derivative displays potently greater antiproliferative activity in GC cells 28 . Altogether, we demonstrated the antitumor activity of formononetin on GC in vitro and in vivo.…”

Section: Discussionsupporting

confidence: 61%

Formononetin exhibits anticancer activity in gastric carcinoma cell and regulatingmiR‐542‐5p

Wang

Zhao

2020

The Kaohsiung J of Med Scie

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Formononetin exhibits anti‐neoplastic activities in specific types of cancers, such as colon carcinoma and breast cancer. Nevertheless, its role in suppressing gastric carcinoma (GC) growth and metastatic‐associated phenotypes has not been fully understood. Here, we demonstrated that formononetin decreased the viability of GC cell line SGC‐7901 and MGC‐803. Furthermore, formononetin suppressed the migration and invasion abilities of GC cells. Consistent with the results in vitro, the anticancer effect of formononetin was verified using xenograft model. The expression of microRNA‐542‐5p (miR‐542‐5p), acted as an oncogene in many cancers, was identified to be upregulated in GC. Importantly, miR‐542‐5p might involve in formononetin exhibits anticancer activity in GC cells. Taken together, these results indicate that formononetin inhibits the growth and aggressiveness of GC cells in vitro and in vivo.

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Section: Discussionsupporting

confidence: 61%

Formononetin exhibits anticancer activity in gastric carcinoma cell and regulatingmiR‐542‐5p

Wang

Zhao

2020

The Kaohsiung J of Med Scie

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“…To achieve high potency, formononetin was modified with a coumarin unit to design a derivate 10 via the molecular hybridization strategy. The analog 10 presented anti-proliferative effects through Wnt/β-catenin pathway in gastric cancer [103]. Besides, Wogonin, a major flavonoid compound isolated from Scutellaria radix, decreased intracellular levels of Wnt proteins and activated degradation β-catenin for proteasomal degradation [104].…”

Section: Natural Agents and New Activity Of Old Drugsmentioning

confidence: 99%

Targeting the Wnt/β-catenin signaling pathway in cancer

2020

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The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investigations highlight the therapeutic potential of agents targeting Wnt/β-catenin signaling in cancer. Wnt ligand/ receptor interface, β-catenin destruction complex and TCF/β-catenin transcription complex are key components of the cascade and have been targeted with interventions in preclinical and clinical evaluations. This scoping review aims at outlining the latest progress on the current approaches and perspectives of Wnt/β-catenin signaling pathway targeted therapy in various cancer types. Better understanding of the updates on the inhibitors, antagonists and activators of Wnt/β-catenin pathway rationalizes innovative strategies for personalized cancer treatment. Further investigations are warranted to confirm precise and secure targeted agents and achieve optimal use with clinical benefits in malignant diseases.

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“…Formononetin is an active ingredient of a traditional Chinese herb, Radix Astragali, and may also be extracted from the inflorescence and flowered branches and leaves of the leguminous plant, Trifolium pratense L. and the whole leaf of Ononis spinosa L ( 8 , 9 ). The anticancer properties of formononetin have been investigated in numerous studies ( 10 – 12 ). An increasing number of studies have also begun to focus on its potential in treating other disease types.…”

Section: Introductionmentioning

confidence: 99%

Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway

2021

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Formononetin has proven to be anti-inflammatory and able to alleviate symptoms of certain allergic diseases. The present study aimed to determine and elucidate the potential effects of formononetin in allergic rhinitis. JME/CF15 cells were pretreated with formononetin at different doses, followed by stimulation with IL-13. Cell Counting Kit-8 assay was performed to determine the cytotoxicity of formononetin. The expression levels of inflammation-related proteins, histamine, IgE, TNF-α, IL-1β, IL-6, granulocyte-macrophage colony-stimulating factor and eotaxin in IL-13-stimulated JME/CF15 cells were detected using ELISAs. The expression levels of phosphorylated-NF-κB p65, NF-κB p65 and cyclooxygenase-2 (Cox-2) were analyzed using western blotting. Reverse transcription-quantitative PCR, western blotting and immunofluorescence were performed to measure the levels of mucin 5AC oligomeric mucus/gel-forming. Expression levels of sirtuin 1 (SIRT1) and nuclear erythroid factor 2-related factor 2 (Nrf2) proteins were also measured using western blotting. The results of the present study revealed that formononetin exerted no cytotoxic effect on the viability of JME/CF15 cells. Following stimulation of JME/CF15 cells with IL-13, formononetin suppressed the upregulated expression levels of proinflammatory cytokines. IL-13-induced formation of mucus was also attenuated by formononetin treatment. Furthermore, it was found that the SIRT1/Nrf2 signaling pathway was activated in formononetin-treated JME/CF15 cells, whereas treatment with the SIRT1 inhibitor, EX527, reversed the effects of formononetin on IL-13-induced inflammation and mucus formation in JME/CF15 cells. In conclusion, the findings of the current study indicated that formononetin may activate the SIRT1/Nrf2 signaling pathway, thereby inhibiting IL-13-induced inflammation and mucus formation in JME/CF15 cells. These results suggested that formononetin may represent a promising agent for the treatment of allergic rhinitis.

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Discovery and anticancer evaluation of a formononetin derivative against gastric cancer SGC7901 cells

Cited by 25 publications

References 35 publications

Formononetin exhibits anticancer activity in gastric carcinoma cell and regulatingmiR‐542‐5p

Formononetin exhibits anticancer activity in gastric carcinoma cell and regulatingmiR‐542‐5p

Targeting the Wnt/β-catenin signaling pathway in cancer

Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway

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