Abstract:The identification of genes and pathways responsible for the transformation of normal cellsinto malignant ones represents a pivotal step to understand the aetiology of cancer, to characterise progression and relapse, and to ultimately design targeted therapies. The advent of high-throughput omic technologies has enabled the discovery of a significant number of cancer driver genes, but recent genomic studies have shown these to be only necessary but not sufficient to trigger tumorigenesis. Since most biologic… Show more
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