Discovering and overcoming the bias in neoantigen identification by unified machine learning models
Ziting Zhang,
Wenxu Wu,
Lei Wei
et al.
Abstract:Neoantigens, formed by genetic mutations in tumor cells, are abnormal peptides that can trigger immune responses. Precisely identifying neoantigens from vast mutations is the key to tumor immunotherapy design. There are three main steps in the neoantigen immune process, i.e., binding with MHCs, extracellular presentation, and induction of immunogenicity. Various machine learning methods have been developed to predict the probability of one of the three events, but the overall accuracy of neoantigen identificat… Show more
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