Discorhabdin D, an antitumor alkaloid from the sponges Latrunculia brevis and Prianos sp

Perry, Nigel B.; Blunt, John W.; Munro, Murray H. G.; Higa, Tatsuo; Sakai, Ryuichi

doi:10.1021/jo00252a052

Cited by 141 publications

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“…The members of this genus are predominately distributed in cold-water regions of the Southern Hemisphere [3,4]. Continuing reports of pyrroloiminoquinone-type alkaloids with strong anticancer activity from Latrunculia sponges have been the main driving force for in-depth chemical analyses of this genus [5][6][7][8][9][10][11][12]. So far, Latrunculia sponges represent one of the major reservoirs of pyrroloiminoquinone-type alkaloids.…”

Section: Introductionmentioning

confidence: 99%

New Discorhabdin B Dimers with Anticancer Activity from the Antarctic Deep-Sea Sponge Latrunculia biformis

Janussen

Taşdemir

2020

Marine Drugs

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Section: Introductionmentioning

confidence: 99%

New Discorhabdin B Dimers with Anticancer Activity from the Antarctic Deep-Sea Sponge Latrunculia biformis

Janussen

Taşdemir

2020

Marine Drugs

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“…Among all marine organisms, sponges represent one of the most promising source of marine bioactive compounds particularly for pharmaceutical leads [5,6]. In order to purify new active compounds with biological activities and potential application in biomedicine, extracts from marine sponges around the world have been examined for antineoplastic activity in various tumor cell lines, as well as in animal models [7][8][9][10][11][12][13][14]. At least two drugs (Ara-A and Ara-C) synthetically derived from sponge metabolites have been clinically used in long-term cancer treatments [15].…”

Section: Introductionmentioning

confidence: 99%

Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture

et al. 2008

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Marine sponges have been prominently featured in the area of cancer research. Here, we examined the anti-proliferative effects of crude extracts (aqueous and organic) of the Brazilian marine sponge Polymastia janeirensis in the U138MG human glioma cell line. Moreover, we examined the effects of extracts on selective cytotoxicity in the glioma cells in comparison with a normal cell culture. Exposure of glioma cells to treatments (24 h) resulted in cell number decrease at all doses tested, with both aqueous and organic extracts (IC(50) <20 and <30 microg/ml, respectively). Parallel to this result, sponge extracts reduced glioma cell viability (IC(50) <15 microg/ml for both extracts). However, higher doses (50 and 100 microg/ml) induced a stronger cytotoxic effect when compared to the lower dose tested (10 microg/ml), inhibiting more than 80% of cellular growth and viability. Propidium iodide uptake and flow cytometry analysis further showed that sponge extracts caused necrosis in the glioma cell line at higher doses, while a high percentage of apoptotic glioma cells were observed at 10 microg/ml. Moreover, apoptosis was prevented by the pan-caspase inhibitor Z-VAD, suggesting that marine sponge extracts, at lower doses, induce caspase-dependent apoptosis in U138MG glioma cells. Surprisingly the extracts herein tested were more effective than temozolomide, a potent inductor of apoptosis used for the treatment of malignant gliomas. Furthermore, our results suggested a selectivity cytotoxic effect on glioma cell line in comparison with a normal cell culture, since the effect on viability found in glioma cells was not observed in astrocyte cultures with the lower dose (10 microg/ml). Thus, this marine sponge may be considered a good candidate for development of new cancer medicines with antitumor activity against gliomas.

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“…Latrunculia brevis sensu Perry et al 1988b (UOC 85NP2-8, UOC 85NP3-1, UOC 85NP5-7, examined) from New Plymouth belongs in this group and is likely to be another new species. The distribution of the populations of Latrunculia in this area is extremely patchy and efforts to recollect additional material for genetic and morphological studies were unproductive.…”

Section: Key To the Species Of Latrunculia In New Zealandmentioning

confidence: 98%

Taxonomic revision of the genusLatrunculiaDu Bocage (Porifera: Demospongiae: Latrunculiidae) in New Zealand

Alvarez

Bergquist

Battershill

2002

New Zealand Journal of Marine and Freshwater Research

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The genus Latrunculia in New Zealand was believed to be represented by at least three species: L. brevis Ridley & Dendy and two undescribed species. However, results from recent studies indicate that the genus contained a complex of at least eight genetically distinct species. In this paper we revise the taxonomy of Latrunculia in New Zealand and describe nine new species. Eight of these were previously identified using genetic techniques (i.e., L. kaakaariki sp. nov., L. duckworthi sp. nov., L. procumbens sp. nov., L. wellingtonensis sp. nov., L. kaikoura sp. nov., L. triverticillata sp. nov., L. fiordensis sp. nov., and L. millerae sp. nov.) and one (L. oxydiscorhabda sp. nov.) was distinguished based only on morphological differences. The species described fall into two morphological groups, spinispiraefera and triverticillata, which can be diagnosed by the number of whorls present along the † Author for correspondence. antarctica, L. lendenfeldi, L. spinispiraefera) is discussed; all of these species are considered to be valid but not conspecific with any of the species described here.

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Discorhabdin D, an antitumor alkaloid from the sponges Latrunculia brevis and Prianos sp

Cited by 141 publications

References 0 publications

New Discorhabdin B Dimers with Anticancer Activity from the Antarctic Deep-Sea Sponge Latrunculia biformis

New Discorhabdin B Dimers with Anticancer Activity from the Antarctic Deep-Sea Sponge Latrunculia biformis

Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture

Taxonomic revision of the genusLatrunculiaDu Bocage (Porifera: Demospongiae: Latrunculiidae) in New Zealand

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