Discordance Between Spatial Distributions of Y-Chromosomal and Mitochondrial Haplotypes in African Green Monkeys (Chlorocebus spp.): A Result of Introgressive Hybridization or Cryptic Diversity?

Haus, Tanja; Roos, Christian; Zinner, Dietmar

doi:10.1007/s10764-013-9717-5

Cited by 16 publications

(14 citation statements)

References 22 publications

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“…Moreover, there is evidence for ancient and ongoing intrageneric hybridization between most species of these genera in areas where their ranges meet [6,12,[56][57][58][59]. Continuing hybridization over generations may lead to the transfer of certain genes into the genome of another species, a process called 'introgression'.…”

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confidence: 99%

Genome typing of nonhuman primate models: implications for biomedical research

et al. 2014

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The success of personalized medicine rests on understanding the genetic variation between individuals. Thus, as medical practice evolves and variation among individuals becomes a fundamental aspect of clinical medicine, a thorough consideration of the genetic and genomic information concerning the animals used as models in biomedical research also becomes critical. In particular, nonhuman primates (NHPs) offer great promise as models for many aspects of human health and disease. These are outbred species exhibiting substantial levels of genetic variation; however, understanding of the contribution of this variation to phenotypes is lagging behind in NHP species. Thus, there is a pivotal need to address this gap and define strategies for characterizing both genomic content and variability within primate models of human disease. Here, we discuss the current state of genomics of NHP models and offer guidelines for future work to ensure continued improvement and utility of this line of biomedical research.

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confidence: 99%

Genome typing of nonhuman primate models: implications for biomedical research

et al. 2014

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“…Hybridization among the different Chlorocebus species has been extensively reported at borders of the geographic ranges of the different species (Groves, 2001; Haus et al, 2013b), and could thus be at the origin of the emergence of this recombinant SIVagmSAB/TAN strain which became subsequently established in certain AGM populations. It is also interesting to note that SIVagmSAB infecting C. sabaeus monkeys has a mosaic structure (Jin et al, 1994) with Gag and Pol proteins more closely related to HIV-2/SIVsmm than to SIVagmGRI and SIVagmVER, while Env and Nef proteins, clustered with other SIVagm lineages illustrating that cross-species transmission and recombination played a role in SIV evolution in the Chlorocebus species.…”

Section: Discussionmentioning

confidence: 96%

Molecular characterization of a new mosaic Simian Immunodeficiency Virus in a naturally infected tantalus monkey (Chlorocebus tantalus) from Cameroon: A challenge to the virus–host co-evolution of SIVagm in African green monkeys

Ayouba

Njouom

Chia

et al. 2015

Infection, Genetics and Evolution

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African green monkeys (AGMs) represent the most widely distributed non-human primates species in Africa. SIVagm naturally infects four of the 6 AGMs species at high prevalence in a species-specific manner. To date, only limited information is available on molecular characteristics of SIVagm infecting Chlorocebus tantalus. Here, we characterized the full-length genome of a virus infecting a naturally infected captive C. tantalus from Cameroon by amplifying and sequencing sub-genomic PCR fragments. The isolate (SIVagmTAN-CM545) is 9923 bp long and contained all canonical genes of a functional SIV. SIVagmTAN-CM545 showed a mosaic structure, with gag, pol, nef and accessory genes closely related to SIVagmSAB infecting Chlorocebus sabaeus monkeys from west Africa, and the env gene, closely related to SIVagmTAN infecting tantalus monkeys from Central Africa. Thus SIVagmTAN-CM545 is SIVagmSAB/SIVagmTAN recombinant. These unexpected findings suggest that the evolution of SIVagm is more complex than previously thought and warrant further studies.

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“…In the case of Chlorocebus , Perelman et al (2011) included C. aethiops , C. sabaeus , and C. cynosures , but not C. pygerythrus . However, given how closely related the species within the genus Chlorocebus are, and current debates regarding species versus subspecies status (Elton, Dunn, & Cardini, 2010; Grubb et al, 2003; Haus, Roos, & Zinner, 2010), the average genetic distance between all Chlorocebus taxa and M. mulatta (99.98 units) and M. fascicularis (100.25 units), respectively, were calculated. As the resultant genetic distances are species, but not sex, specific, and in order to provide a point of comparison with the two morphological distance matrices where sex and species were considered separately, the genetic distance among sexes of the same species were considered to be zero.…”

Section: Methodsmentioning

confidence: 99%

The relative efficacy of the cranium and os coxa for taxonomic assessment in macaques

Kenyon-Flatt

Conaway

Lycett

et al. 2020

American J Phys Anthropol

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Objectives The cranium is generally considered more reliable than the postcranium for assessing primate taxonomy, although recent research suggests that pelvic shape may be equally reliable. However, little research has focused on intrageneric taxonomic discrimination. Here, we test the relative taxonomic efficacy of the cranium and os coxa for differentiating two macaque species, with and without considering sexual dimorphism. Materials and methods Geometric morphometric analyses were performed on cranial and os coxa landmarks for 119 adult Macaca fascicularis, M. mulatta, and Chlorocebus pygerythrus. Among‐group shape variation was examined using canonical variates analyses. Cross‐validated discriminant function analysis provided rates of correct group classification. Additionally, average morphological distances were compared with neutral genetic distances. Results Macaque species were clearly differentiated, both cranially and pelvically, when sex was not considered. Males were more often correctly classified based on the os coxa, while female classification rates were high for both morphologies. Female crania and male os coxa were differentiated approximately the same as genetic distance, while male crania were more similar (convergent), and female os coxa were more divergent than expected based on genetic distance. Discussion The hypothesis that cranial and os coxal shape can be used to discriminate among macaque species was supported. The cranium was better at differentiating females, while the os coxa was better at differentiating male macaques. Hence, there is no a priori reason for preferring the cranium when assessing intragenetic taxonomic relationships, but the effects of high levels of sexual dimorphism must be corrected for to accurately assess taxonomic signatures.

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Discordance Between Spatial Distributions of Y-Chromosomal and Mitochondrial Haplotypes in African Green Monkeys (Chlorocebus spp.): A Result of Introgressive Hybridization or Cryptic Diversity?

Cited by 16 publications

References 22 publications

Genome typing of nonhuman primate models: implications for biomedical research

Genome typing of nonhuman primate models: implications for biomedical research

Molecular characterization of a new mosaic Simian Immunodeficiency Virus in a naturally infected tantalus monkey (Chlorocebus tantalus) from Cameroon: A challenge to the virus–host co-evolution of SIVagm in African green monkeys

The relative efficacy of the cranium and os coxa for taxonomic assessment in macaques

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