Discontinuation of low dose aspirin and risk of myocardial infarction: case-control study in UK primary care

Abstract

Objectives To evaluate the risk of myocardial infarction and death from coronary heart disease after discontinuation of low dose aspirin in primary care patients with a history of cardiovascular events.

Frequency and Predictors of Non-Compliance to Aspirin Therapy in Post Myocardial Infarction Patients

“…Treatment cessation with aspirin has been shown to be an independent risk factor of an increase in mortality after acute coronary syndrome (Collet et al, 2004). A case control study in UK determined non-compliance to aspirin to be a major predictor of non-fatal MI in patients with a history of ischemic events (Rodríguez, Cea-Soriano, Martín-Merino, & Johansson, 2011), while another study reported the possibility of two vascular events being avoided each day if aspirin were used at a maximum level, with 100% compliance (Morgan, 2012). Other studies indicate premature discontinuation of antiplatelet therapy to be strongly associated with an increased risk of stent thrombosis and death (Rossini et al, 2011).…”

The Impact of Antiplatelet Medication on Hand and Wrist Surgery

“…In a case-control study of patients taking daily low dose aspirin, an increased risk of myocardial infarction was noted in patients who discontinued aspirin therapy. [12] The risk associated with stopping antiplatelet treatment appears well within a normal perioperative window with 1 study reporting a 3-fold increased occurrence of myocardial infarction an average of 10 days after acute withdrawal of aspirin. [13] Furthermore, the mortality associated with acute coronary syndrome has been shown to be increased in patients who have recently discontinued aspirin therapy whether used for primary or secondary prevention.…”

Gestion péri-opératoire des patients traités par antithrombotiques en chirurgie orale. Argumentaire

“…S32 patients ayant interrompu leur traitement par aspirine durant la période postopératoire immédiate et dans le mois suivant [25,30,60,64,65,102,103,112,116,127,214,277]. Dans une méta-analyse [40], l'arrêt de l'aspirine chez un patient sous aspirine au long cours est associé une augmentation du risque d'évènement thrombotique (cardiaque ou neurologique) d'un facteur trois (OR 3,14 , IC à 95 % de 1,75 à 5,61, p < 0,05).…”