Disconnection of the cerebral hemispheres

Wilson, Donald H.; Culver, Caroline; Waddington, Margaret M.; Gazzaniga, Michael S.

doi:10.1212/wnl.25.12.1149

Cited by 88 publications

(17 citation statements)

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“…The left and right HPCs are directly connected by the hippocampal commissure (Wilson, Culver, Waddington, & Gazzaniga, 1975), and their activities show definite synchronization (Goto et al, 2010). Consistently, all the subjects enrolled in this study showed significant correlations between the left and right HPCs in terms of the BOLD signal changes with time in resting-state functional MRI.…”

Section: Discussionsupporting

confidence: 82%

Can We Find Any Sustained Neurofunctional Alteration in Remitted Depressive Patients with a History of Modified Electroconvulsive Therapy?

Saito¹,

Fujihara²,

Kasagi³

et al. 2017

OJD

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Background and Aim: Recent magnetic resonance imaging (MRI) studies have revealed structural and functional differences in the human brain before and after an electroconvulsive therapy (ECT) series in patients with depression. The hippocampus is one of the well-documented subcortical areas that show an increase in cortical volume following an ECT series. Moreover, some resting-state functional MRI studies have shown that an ECT series alters the connectivities of the hippocampus with several brain areas. However, it remains unknown whether ECT can induce some sustained neurofunctional alterations in the human brain. Methods: In this study of the depressive patients with and without a history of modified ECT (N = 5 and 9, respectively) using a cross-sectional design, we investigated the functional connectivity between the left and right hippocampi in terms of blood-oxygenation-level dependent signal changes with time by resting-state functional MRI. Results: Voxel-based morphometry showed no significant structural differences in hippocampal volume between the ECT and non-ECT groups. The ECT group showed a significantly lower functional connectivity between the same brain areas than the non-ECT group (p < 0.01). Conclusions: Although their clinical significance remains unclear, our results suggest that an ECT series induces a sustained neurofunctional alteration in the human brain.

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Section: Discussionsupporting

confidence: 82%

Can We Find Any Sustained Neurofunctional Alteration in Remitted Depressive Patients with a History of Modified Electroconvulsive Therapy?

Saito¹,

Fujihara²,

Kasagi³

et al. 2017

OJD

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“…In the early 1960s, Bogen reported a small series of similarly operated patients with encouraging results [12,13,14], and Luessenhop described comparable success in three of four children [123,124]. In 1971, Wilson chose this procedure as an alternative to hemispherectomy in a 9-year-old boy with infantile hemiplegia and began compiling a series of 20 patients that ultimately revealed the efficacy of the procedure, warranting its wider application [74,169,271,272,273,274,275].…”

Section: Callosotomymentioning

confidence: 99%

Presurgical evaluation and surgical treatment of medically refractory epilepsy

Siegel

2004

Neurosurgical Review

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Thanks to today's modern imaging examination techniques and especially to the common use of intracranial electrodes for localizing seizure foci, more and more patients with partial epilepsy can be treated microsurgically. The results of such neurosurgical therapies are very good, particularly in mesial temporal lobe epilepsy. In recent years, good results (60-70% seizure freedom) have also been achieved in extratemporal epilepsy surgery, so that such procedures can now be recommended for carefully selected patients. In this review, presurgical evaluations and the different surgical approaches are presented.

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“…They divided the corpus callosum as well as the anterior commissure, massa intermedia, and one fornix. With the introduction of microsurgical technique the pro cedure has been refined, with concomitant reductions in morbidity and mortality [2][3][4][5][6]. Corpus callosotomy is now a safe and effective treatment for patients with intractable epilepsy, particularly for those susceptible to injury from drop attacks [7].…”

Section: Introductionmentioning

confidence: 99%

Corpus Callosotomy for Medically Intractable Seizures

Jm¹,

Jw²,

Je³

et al. 1997

Pediatr Neurosurg

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To identify factors influencing outcome and morbidity in patients selected for corpus callosotomy, we retrospectively reviewed 23 patients with intractable generalized seizures who underwent corpus callosotomy between 1991 and 1994. Three patients had a complete corpus callosotomy, while 20 had an anterior callosotomy. Three of those patients subsequently had completion of the anterior callosotomy. Overall, 41% of patients were nearly or completely free of the seizure types targeted for surgical treatment, while another 45 % had seizures less than half as frequently. Four patients developed simple partial motor seizures after callosotomy. A transient disconnection syndrome was observed in 57% of patients. The best predictor of good outcome was a normal preoperative MRI. Mentally retarded patients had poorer outcomes. Outcome was not predicted by extent of callosal section or lateralization on neurological examination, EEG, MRI, and SPECT. Completion of anterior callosotomy resulted in significant reductions in seizure frequency. Though most patients do not become seizure-free after corpus callosotomy, worthwhile palliation of an otherwise intractable illness can be achieved. An analysis of prognostic factors should lead to better selection of patients for surgery.

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Disconnection of the cerebral hemispheres

Cited by 88 publications

References 0 publications

Can We Find Any Sustained Neurofunctional Alteration in Remitted Depressive Patients with a History of Modified Electroconvulsive Therapy?

Can We Find Any Sustained Neurofunctional Alteration in Remitted Depressive Patients with a History of Modified Electroconvulsive Therapy?

Presurgical evaluation and surgical treatment of medically refractory epilepsy

Corpus Callosotomy for Medically Intractable Seizures

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