Disclosure of familial implications of pathogenic variants in breast-cancer genes to patients: Opportunity for prompting family communication

Makhnoon, Sukh; Smith, Hadley Stevens; Bednar, Erica M.; Bhatt, Arjun; Turner, Llaran L.; Arun, Banu K.; Volk, Robert J.; Peterson, Susan K.

doi:10.1007/s12687-021-00504-9

J Community Genet

2021

DOI: 10.1007/s12687-021-00504-9

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Disclosure of familial implications of pathogenic variants in breast-cancer genes to patients: Opportunity for prompting family communication

Sukh Makhnoon

Hadley Stevens Smith

Erica M. Bednar

et al.

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Cited by 3 publications

(1 citation statement)

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“…Makhnoon et al 22 reported that only 41.6% of the patients—with positive pathogenic variants in BC genes—who visited the University of Texas MD Anderson Cancer for genetic counseling were eager to disclose their results to family members. Would Arab population have similar problem?…”

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confidence: 99%

High Number of Familial Breast Cancer Cases in the Arabian Gulf Countries: Investigating the Reasons

Mohammed

2022

Breast Cancer�(Auckl)

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mentioning

confidence: 99%

High Number of Familial Breast Cancer Cases in the Arabian Gulf Countries: Investigating the Reasons

Mohammed

2022

Breast Cancer�(Auckl)

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Helping Patients Understand and Cope with BRCA Mutations

2022

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Improving our model of cascade testing for hereditary cancer risk by leveraging patient peer support: a concept report

O’Neill¹,

Hamilton

Conley³

et al. 2021

Hered Cancer Clin Pract

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Consensus and evidence suggest that cascade testing is critical to achieve the promise of cancer genetic testing. However, barriers to cascade testing include effective family communication of genetic risk information and family members’ ability to cope with genetic risk. These barriers are further complicated by the developmental needs of unaffected family members during critical windows for family communication and adaptation. Peer support could address these barriers. We provide two illustrative examples of ongoing BRCA1/2-related clinical trials that apply a peer support model to improve family communication and functioning. Peer support can augment currently available genetic services to facilitate adjustment to and effective use of cancer genetic risk information. Importantly, this scalable approach can address the presence of cancer risk within families across multiple developmental stages. This applies a family-centered perspective that accommodates all potentially at-risk relatives. This peer support model can be further applied to emerging topics in clinical genetics to expand reach and impact.

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Disclosure of familial implications of pathogenic variants in breast-cancer genes to patients: Opportunity for prompting family communication

Cited by 3 publications

References 22 publications

High Number of Familial Breast Cancer Cases in the Arabian Gulf Countries: Investigating the Reasons

High Number of Familial Breast Cancer Cases in the Arabian Gulf Countries: Investigating the Reasons

Helping Patients Understand and Cope with BRCA Mutations

Improving our model of cascade testing for hereditary cancer risk by leveraging patient peer support: a concept report

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