Discharges of Purkinje cells in the paravermal part of the cerebellar anterior lobe during locomotion in the cat.

Armstrong, David M.; Edgley, S A

doi:10.1113/jphysiol.1984.sp015300

Cited by 137 publications

(97 citation statements)

References 28 publications

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“…Across all 72 Purkinje cells, mean baseline simple spike firing rate calculated from a recording period before CS onset was 26.3 spikes/sec (range = 10.0 to 109.6 spikes/sec). This broad range of tonic activity of simple spikes in Purkinje cells recorded in vivo agrees with many previous studies (Thach 1968;Armstrong and Rawson 1979;Armstrong and Edgley 1984;Edgley and Lidierth 1987). Purkinje cells in the areas we recorded from appeared responsive to the corneal air puff, as bursts of complex spikes could be observed during US-alone trials (Fig.…”

Section: Cerebellar Anterior Lobe Activitysupporting

confidence: 78%

“…Given that the mossy fiber-granule cell-parallel fiber pathway conveys both auditory (Aitkin and Boyd 1975) and tactile (Armstrong and Edgley 1984) information to the cortex, which is represented in Purkinje cells by simple spiking, it might be suggested that the changes in simple spiking after eyeblink conditioning that we observed were more stimulus-than response-related (i.e., CS-and US-related, but not CRrelated). However, the fact that, at least in some Purkinje cells, changes in simple spiking appeared to be related to the CS-US interval suggests that the activity we observed was more than just stimulus-related and may have represented a temporal code.…”

Section: Ditioning (Mccormick and Thompson 1984; Berthier And Moorementioning

confidence: 57%

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Purkinje cell activity in the cerebellar anterior lobe after rabbit eyeblink conditioning

Green¹,

Steinmetz²

2005

Learn. Mem.

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The cerebellar anterior lobe may play a critical role in the execution and proper timing of learned responses. The current study was designed to monitor Purkinje cell activity in the rabbit cerebellar anterior lobe after eyeblink conditioning, and to assess whether Purkinje cells in recording locations may project to the interpositus nucleus. Rabbits were trained in an interstimulus interval discrimination procedure in which one tone signaled a 250-msec conditioned stimulus-unconditioned stimulus (CS-US) interval and a second tone signaled a 750-msec CS-US interval. All rabbits showed conditioned responses to each CS with mean onset and peak latencies that coincided with the CS-US interval. Many anterior lobe Purkinje cells showed significant learning-related activity after eyeblink conditioning to one or both of the CSs. More Purkinje cells responded with inhibition than with excitation to CS presentation. In addition, when the firing patterns of all conditioning-related Purkinje cells were pooled, it appeared that the population showed a pattern of excitation followed by inhibition during the CS-US interval. Using cholera toxin-conjugated horseradish peroxidase, Purkinje cells in recording areas were found to project to the interpositus nucleus. These data support previous studies that have suggested a role for the anterior cerebellar cortex in eyeblink conditioning as well as models of cerebellar-mediated CR timing that postulate that Purkinje cell activity inhibits conditioned response (CR) generation during the early portion of a trial by inhibiting the deep cerebellar nuclei and permits CR generation during the later portion of a trial through disinhibition of the cerebellar nuclei.Eyeblink classical conditioning has been used with great success to study the involvement of the cerebellum in motor learning. In eyeblink conditioning, a conditioned stimulus (CS), usually a tone, precedes an unconditioned stimulus (US), usually a corneal air puff, by 250-750 msec. Initially, the air puff US elicits a reliable response, in the form of a reflexive eye blink that is called an unconditioned response (UR). Over the course of a few hundred paired CS-US trials, an eye blink to the CS develops, which has a longer latency than the UR and differs in topography. This learned response is called the conditioned response (CR). One of the deep cerebellar nuclei, the interpositus nucleus, appears to be critical for learning CRs during eyeblink conditioning (e.g., Lavond et al. 1985;Yeo et al. 1985a;). In addition, lesions of some regions of cerebellar cortex (i.e., Larsell's lobule HVI) have been reported to affect CR production (e.g., Yeo et al. 1985b;Lavond and Steinmetz 1989) and recordings of Purkinje cell activity in this area have revealed inhibitory and excitatory patterns of activity that appear to be related to CS or US presentation and CR execution (e.g., Berthier and Moore 1986; Katz and Steinmetz 1997).Mauk and colleagues have presented data suggesting that another region of the cerebellar cortex, the cerebellar a...

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Section: Cerebellar Anterior Lobe Activitysupporting

confidence: 78%

Section: Ditioning (Mccormick and Thompson 1984; Berthier And Moorementioning

confidence: 57%

Purkinje cell activity in the cerebellar anterior lobe after rabbit eyeblink conditioning

Green¹,

Steinmetz²

2005

Learn. Mem.

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“…These receptive fields bear a striking similarity to those of the Purkinje cells in this region of cortex (Armstrong & Edgley, 1984b;S. A. Edgley & M. Lidierth, in preparation).…”

Section: Peripheral Receptive Fields Of Golgi Cellsmentioning

confidence: 66%

“…Firstly, and most importantly, none of them ever discharged potentials resembling complex spikes. Secondly, their action potentials were of long duration, ranging from 0-8 to 2-0 ms (as compared to 0-3-1P0 ms for Purkinje cells, see Armstrong & Edgley, 1984b). The action potentials from three different units are illustrated in Fig.…”

Section: Resultsmentioning

confidence: 99%

The discharges of cerebellar Golgi cells during locomotion in the cat.

Edgley¹,

Lidierth²

1987

The Journal of Physiology

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SUMMARY1. Extracellular recordings have been obtained from 134 units in the paravermal cortex of lobule V in the anterior lobe of the cerebellum in free-to-move cats. Each unit discharged action potentials in a characteristic pattern with no complex spikes. Previous investigators have described such discharges and have assigned them to Golgi cells. We provide further evidence to support this identification.2. In cats which were sitting quietly, each putative Golgi cell discharged tonically at a low rate (overall mean (±S.D.) was 14-5+7-3 spikes/s). Eighty-one of the neurones were also recorded during steady walking on a moving belt and the discharge rate then averaged 17-7 (S.D. + 19-4) spikes/s.3. All eighty-one putative Golgi cells discharged rythmically during locomotion. Many different patterns of discharge were seen but as a population the neurones were most active in early stance and at the onset of the swing phase of the step cycle in the ipsilateral forelimb.4. Over a range of different walking speeds (0 5-09 m/s) and of different uphill inclines (0-25 deg), putative Golgi cells discharged with similar patterns and rates, despite large changes in the vigour of the locomotor movements and in the amplitude of limb muscle electromyograms.

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“…The climbing fiber-driven complex spike activity (Thach, 1967;Armstrong and Edgley, 1984) of a single Purkinje cell recorded at the same location is also illustrated ( Fig. 2 B, raw traces; C, raster and peristimulus time histogram).…”

Section: Resultsmentioning

confidence: 99%

Electrophysiological Localization of Eyeblink-Related Microzones in Rabbit Cerebellar Cortex

Mostofi¹,

Holtzman²,

Grout³

et al. 2010

Journal of Neuroscience

102

116

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The classically conditioned eyeblink response in the rabbit is one of the best-characterized behavioral models of associative learning. It is cerebellum dependent, with many studies indicating that the hemispheral part of Larsell's cerebellar cortical lobule VI (HVI) is critical for the acquisition and performance of learned responses. However, there remain uncertainties about the distribution of the critical regions within and around HVI. In this learning, the unconditional stimulus is thought to be carried by periocular-activated climbing fibers. Here, we have used a microelectrode array to perform systematic, high-resolution, electrophysiological mapping of lobule HVI and surrounding folia in rabbits, to identify regions with periocular-evoked climbing fiber activity. Climbing fiber local field potentials and single-unit action potentials were recorded, and electrode locations were reconstructed from histological examination of brain sections. Much of the sampled cerebellar cortex, including large parts of lobule HVI, was unresponsive to periocular input. However, short-latency ipsilateral periocular-evoked climbing fiber responses were reliably found within a region in the ventral part of the medial wall of lobule HVI, extending to the base of the primary fissure. Small infusions of the AMPA/kainate receptor antagonist CNQX into this electrophysiologically defined region in awake rabbits diminished or abolished conditioned responses. The known parasagittal zonation of the cerebellum, supported by zebrin immunohistochemistry, indicates that these areas have connections consistent with an essential role in eyeblink conditioning. These small eyeblink-related areas provide cerebellar cortical targets for analysis of eyeblink conditioning at a neuronal level but need to be localized with electrophysiological identification in individual animals.

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Discharges of Purkinje cells in the paravermal part of the cerebellar anterior lobe during locomotion in the cat.

Cited by 137 publications

References 28 publications

Purkinje cell activity in the cerebellar anterior lobe after rabbit eyeblink conditioning

Purkinje cell activity in the cerebellar anterior lobe after rabbit eyeblink conditioning

The discharges of cerebellar Golgi cells during locomotion in the cat.

Electrophysiological Localization of Eyeblink-Related Microzones in Rabbit Cerebellar Cortex

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