Discharge rate profiles of paratrigeminal nucleus neurons throughout a pressor event in non-anaesthetized rats

Sousa, L.O.; Lindsey, Charles Julian

doi:10.1016/j.autneu.2008.12.012

Cited by 4 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pa5 microinjection of bradykinin evokes pressor effects (Lindsey et al, ) via direct activation of barosensitive RVLM neurons (Caous et al, ). Many (60–80%) Pa5 neurons are themselves barosensitive, increasing their firing rate in response to phenylephrine administration (Balan et al, ; Sousa and Lindsey, ), while bilateral Pa5 ablation reduces cardiac barosensitivity (Sousa and Lindsey, ). Whether SST participates in mediating such reflex modulation in the RVLM is unknown.…”

Section: Discussionmentioning

confidence: 99%

Somatostatin in the rat rostral ventrolateral medulla: Origins and mechanism of action

Farah

Bowman

Bokiniec

et al. 2015

J of Comparative Neurology

View full text Add to dashboard Cite

Somatostatin (SST) or agonists of the SST-2 receptor (sst2 ) in the rostral ventrolateral medulla (RVLM) lower sympathetic nerve activity, arterial pressure, and heart rate, or when administered within the Bötzinger region, evoke apneusis. Our aims were to describe the mechanisms responsible for the sympathoinhibitory effects of SST on bulbospinal neurons and to identify likely sources of RVLM SST release. Patch clamp recordings were made from bulbospinal RVLM neurons (n = 31) in brainstem slices prepared from juvenile rat pups. Overall, 58% of neurons responded to SST, displaying an increase in conductance that reversed at -93 mV, indicative of an inwardly rectifying potassium channel (GIRK) mechanism. Blockade of sst2 abolished this effect, but application of tetrodotoxin did not, indicating that the SST effect is independent of presynaptic activity. Fourteen bulbospinal RVLM neurons were recovered for immunohistochemistry; nine were SST-insensitive and did not express sst2a . Three out of five responsive neurons were sst2a -immunoreactive. Neurons that contained preprosomatostatin mRNA and cholera-toxin-B retrogradely transported from the RVLM were detected in: paratrigeminal nucleus, lateral parabrachial nucleus, Kölliker-Fuse nucleus, ventrolateral periaqueductal gray area, central nucleus of the amygdala, sublenticular extended amygdala, interstitial nucleus of the posterior limb of the anterior commissure nucleus, and bed nucleus of the stria terminalis. Thus, those brain regions are putative sources of endogenous SST release that, when activated, may evoke sympathoinhibitory effects via interactions with subsets of sympathetic premotor neurons that express sst2 .

show abstract

Section: Discussionmentioning

confidence: 99%

Somatostatin in the rat rostral ventrolateral medulla: Origins and mechanism of action

Farah

Bowman

Bokiniec

et al. 2015

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

“…The predominant innervation of trigeminal second-order neurons by jugular ganglia afferents has only recently been described, although older studies have detailed barosensitive vagal afferent inputs to trigeminal brain stem regions (21,403,404,474). The paratrigeminal nucleus is a diffuse cluster of neurons within the dorsal spinal trigeminal nucleus, and although there have been no discrete electrophysiological studies of second-order neurons receiving airway inputs, electron microscopic studies combined with sensory nerve fiber tracing suggest that at distinct classes of secondorder neurons are synaptically connected with laryngeal afferents in this brain stem region (389).…”

Section: Central Nervous System Terminations and Ascending Pathways A Brain Stemmentioning

confidence: 99%

Vagal Afferent Innervation of the Airways in Health and Disease

Mazzone

Undem

2016

Physiological Reviews

404

510

View full text Add to dashboard Cite

Vagal sensory neurons constitute the major afferent supply to the airways and lungs. Subsets of afferents are defined by their embryological origin, molecular profile, neurochemistry, functionality, and anatomical organization, and collectively these nerves are essential for the regulation of respiratory physiology and pulmonary defense through local responses and centrally mediated neural pathways. Mechanical and chemical activation of airway afferents depends on a myriad of ionic and receptor-mediated signaling, much of which has yet to be fully explored. Alterations in the sensitivity and neurochemical phenotype of vagal afferent nerves and/or the neural pathways that they innervate occur in a wide variety of pulmonary diseases, and as such, understanding the mechanisms of vagal sensory function and dysfunction may reveal novel therapeutic targets. In this comprehensive review we discuss historical and state-of-the-art concepts in airway sensory neurobiology and explore mechanisms underlying how vagal sensory pathways become dysfunctional in pathological conditions.

show abstract

“…Although many baroreceptive afferents terminate centrally in the nucleus of the solitary tract, neurons in the paratrigeminal nucleus also demonstrate baroreceptor-related activity (Caous et al, 2001; de Sousa Buck et al, 2001). In the rat, up to 72% of paratrigeminal neurons are barosensitive and of these almost all show rhythmic activity with the cardiac cycle (Balan Júnior et al, 2004; Sousa and Lindsey, 2009). Importantly, baroreceptor reflex evoked changes in cardiovascular activity is modulated by altering synaptic processing in the paratrigeminal nucleus.…”

Section: The Physiological Role Of the Paratrigeminal Nucleus In Vagamentioning

confidence: 99%

“…Importantly, baroreceptor reflex evoked changes in cardiovascular activity is modulated by altering synaptic processing in the paratrigeminal nucleus. Thus, microinjection of bradykinin into the paratrigeminal nucleus results in increased arterial pressure, while lesioning this nucleus increases resting arterial pressure and heart rate and impairs baroreceptor reflex sensitivity (Lindsey et al, 1997; Sousa and Lindsey, 2009). Although not proven, these effects are presumably mediated by paratrigeminal neuronal connectivity with the ventrolateral medulla.…”

Section: The Physiological Role Of the Paratrigeminal Nucleus In Vagamentioning

confidence: 99%

Vagal Afferent Processing by the Paratrigeminal Nucleus

Driessen

2019

Front. Physiol.

View full text Add to dashboard Cite

The paratrigeminal nucleus is an obscure region in the dorsal lateral medulla, which has been best characterized as a collection of interstitial cells located in the dorsal tip of the spinal trigeminal tract. The paratrigeminal nucleus receives afferent input from the vagus, trigeminal, spinal, and glossopharyngeal nerves, which contribute to its long-known roles in the baroreceptor reflex and nociceptive processing. More recently, studies have shown that this region is also involved in the processing of airway-derived sensory information. Notably, these studies highlight an underappreciated complexity in the neuronal content and circuit connectivity of the paratrigeminal nucleus. However, much remains to be understood about how paratrigeminal processing of vagal afferents is altered in disease. The aim of the present review is to provide an update of the current understanding of vagal afferent processing in the paratrigeminal nucleus and to explore how dysregulation at this site may contribute to vagal sensory neural dysfunction during disease.

show abstract

Discharge rate profiles of paratrigeminal nucleus neurons throughout a pressor event in non-anaesthetized rats

Cited by 4 publications

References 23 publications

Somatostatin in the rat rostral ventrolateral medulla: Origins and mechanism of action

Somatostatin in the rat rostral ventrolateral medulla: Origins and mechanism of action

Vagal Afferent Innervation of the Airways in Health and Disease

Vagal Afferent Processing by the Paratrigeminal Nucleus

Contact Info

Product

Resources

About